| Identification | |
| Name: | 1H-3-Benzazepine-7,8-diol,6-chloro-2,3,4,5-tetrahydro-1-(3-methylphenyl)-3-(2-propen-1-yl)- |
| Synonyms: | 1H-3-Benzazepine-7,8-diol,6-chloro-2,3,4,5-tetrahydro-1-(3-methylphenyl)-3-(2-propenyl)- (9CI); SKF 83822 |
| CAS: | 74115-08-5 |
| Molecular Formula: | C20H22 Cl N O2 |
| Molecular Weight: | 424.76 |
| Molecular Structure: |  |
| Properties | |
| Biological Activity: | High affinity, selective dopamine D 1 -like receptor agonist. K i values are 3.2, 3.1, 186, 66, 335, 1167, 1251 and 1385 nM at recombinant D 1 , D 5 , D 2 , D 3 , D 4 , 5-HT 2A , α 1A and α 1B receptors respectively. Stimulates adenylyl cyclase (EC 50 = 65 nM) but not phosphoinositide hydrolysis. Induces extreme arousal and hyperlocomotion following subcutaneous administration in monkeys. |
| Storage Temperature: | Store at RT |
| Safety Data | |
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