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Lovastatin (75330-75-5)

Identification
Name:Lovastatin
Synonyms:MK-803;Belvas;(1S-(1alpha(R),3alpha,7beta,8beta(2S,4S),8abeta))-(1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthyl) 2-methylbutanoate;Rodatin;Paschol;Artein;Butanoic acid, 2-methyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-- oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1alpha(R*),3alpha,7beta,8beta(2S*,4S*),8abeta))-;Sivlor;MK 803;Mevinolin;Prestwick_819;Antibiotic MB 530B;Lestatin;Colevix;Lovastation;Mevinacor;Lovasterol;[(1S,3R,7R,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxo-oxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate;2-Methyl-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl ester butanoic acid;Hipolip;Tecnolip;Lovastatine [French];6-alpha-Methylcompactin;MSD 803;Cholestra;Lovastatin (USP);ML-530B;Monacolin K;Hipovastin;Taucor;Mevacor (TN);[(1S,3R,7R,8S,8aR)-8-[2-[(4R)-4-hydroxy-6-oxo-oxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate;Teroltrat;Lozutin;Lipofren;Lipdip;
CAS:75330-75-5
Molecular Formula: C24H36O5
Molecular Weight: 404.54
InChI: InChI=1/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3/t14-,15-,16-,18+,19+,20-,21-,23-/m0/s1
Molecular Structure: (C24H36O5) MK-803;Belvas;(1S-(1alpha(R),3alpha,7beta,8beta(2S,4S),8abeta))-(1,2,3,7,8,8a-hexahydro-3,7-dimethyl...
Properties
Transport:3077
Flash Point: 185.3 oC
Boiling Point: 559.2 oC at 760 mmHg
Density:1.12 g/cm3
Solubility:0.0004 mg/mL at 25 oC
Appearance:White solid
Specification:

? Lovastatin ,?its cas register number is?75330-75-5. It also can be called?(1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-(2-(2R,4R)-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl (S)-2-methyl-butyrate ; (S)-2-Methylbutyric acid, 8-ester with (4R,6R)-6-(2-((1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthyl)ethyl)tetrahydro-4-hydroxy-2H-pyran-2-one ; 6-alpha-Methylcompactin ; 6alpha-Methylcompactin ; Cholestra ;
?Lipivas ; Lipofren ; Lovalip; Lovalord ; Lovasterol?; Mevinacor ; Mevinolin ; Mevlor ; Monacolin K ; Nergadan ; Paschol ; Rodatin .

Packinggroup: III
Biological Activity: Potent, competitive inhibitor of HMG-CoA reductase (K i = 0.6 nM) therefore decreases cholesterol biosynthesis, in vitro and in vivo . Decreases CDK2, 4, 6 and cyclin E levels and induces G1 arrest and apoptosis in tumor cell lines in vitro .
Flash Point: 185.3 oC
Color: White crystals
A white, nonhygroscopic crystalline powder
Usage:

An antihypercholesterolemic agent. A fungal metabolite, which is a potent inhibitor of HMG-CoA reductase

Safety Data
Hazard Symbols Xi: Irritant
 

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