| Identification | |
| Name: | Leflunomide |
| Synonyms: | 4-Isoxazolecarboxamide, 5-methyl-N-(4-(trifluoromethyl)phenyl)-;N-(4-Trifluoromethylphenyl)-5-methylisoxazole-4-carboxamide;Leflunomidum [INN-Latin];sell leflunomide;5-methyl-N-[4-(trifluoromethyl)phenyl]oxazole-4-carboxamide;5-Methylisoxazole-4-(4-trifluoromethyl) carboxanilide;Leflunamide;Isoxazole-4-carboxamide, 5-methyl-N-[4-(trifluoromethyl)phenyl]-;5-Methylisoxazole-4-carboxylic acid (4-trifluoromethyl)anilide;Arava;Leflunomida [INN-Spanish]; |
| CAS: | 75706-12-6 |
| Molecular Formula: | C12H9F3N2O2 |
| Molecular Weight: | 270.21 |
| InChI: | InChI=1/C12H9F3N2O2/c1-7-10(6-16-19-7)11(18)17-9-4-2-8(3-5-9)12(13,14)15/h2-6H,1H3,(H,17,18) |
| Molecular Structure: |  |
| Properties | |
| Transport: | UN 2811 6.1/PG 3 |
| Density: | 1.392 g/cm3 |
| Solubility: | Insoluble |
| Appearance: | off white crystalline solid |
| Specification: |
?Leflunomide , its cas register number is 75706-12-6. It also can be called?4-Isoxazolecarboxamide, 5-methyl-N-(4-(trifluoromethyl)phenyl)- ; 5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazolecarboxamide ; 5-Methylisoxazole-4-carboxylic acid (4-trifluoromethyl)anilide ; Arava ; Leflunomida ; Leflunomidum ; N-(4'-Trifluoromethylphenyl)-5-methylisoxazole-4-carboxamide ; alpha,alpha,alpha-Trifluoro-5-methyl-4-isoxazolecarboxy-p-toluidide?.It is a?off white crystalline solid. |
| Color: | Crystals from toluene |
| Usage: | An immunosuppressive. Inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is beleived to inhibit dihydroorotate dehydrogenase as well as several protein tyrosine kinases. Therape |
| Safety Data | |
| Hazard Symbols |
Xn:Harmful
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