| Identification |
| Name: | Phosphoric acid,(4-chlorophenyl)(dimethoxyphosphinyl)methyl dimethyl ester |
| Synonyms: | Mifobate;SR 202 |
| CAS: | 76541-72-5 |
| Molecular Formula: | C11H17 Cl O7 P2 |
| Molecular Weight: | 358.67 |
| InChI: | InChI=1/C11H17ClO7P2/c1-15-20(13,16-2)11(19-21(14,17-3)18-4)9-5-7-10(12)8-6-9/h5-8,11H,1-4H3 |
| Molecular Structure: |
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| Properties |
| Flash Point: | 350.8°C |
| Boiling Point: | 436.6°C at 760 mmHg |
| Density: | 1.355g/cm3 |
| Refractive index: | 1.494 |
| Biological Activity: | Selective PPAR γ antagonist; antidiabetic and antiobesity agent. Attenuates troglitazone-induced PPAR γ transcriptional activity (IC 50 = 140 μ M) without affecting ligand-stimulated PPAR α , PPAR β or FXR transcriptional activity. Inhibits PPAR γ -dependent adipocyte differentiation and growth in vitro and in vivo . Improves insulin sensitivity in diabetic ob/ob mice and increases HDL levels in rats in vivo . |
| Flash Point: | 350.8°C |
| Storage Temperature: | −20°C |
| Color: | white |
| Safety Data |
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