2,5-Pyrrolidinedione,3-ethyl-3-methyl- (77-67-8)

  Ethosuximide with CAS registry number of 77-67-8 is also known as Ethosuximide [USAN:INN:BAN:JAN] ; (+-)-2-Ethyl-2-methylsuccinimide ; 2,5-Pyrrolidinedione, 3-ethyl-3-methyl- ; 2,5-Pyrrolidinedione, 3-ethyl-3-methyl-, (+-)- ; 2-Ethyl-2-methylsuccinimide ; 2-Methyl-2-ethylsuccinimide ; 3-Ethyl-3-methylpyrrolidine-2,5-dione ; 3-Ethyl-3-methylsuccinimide ; 3-Methyl-3-ethylpyrrolidine-2,5-dione ; 3-Methyl-3-ethylsuccinimide ; 5-21-09-00595 (Beilstein Handbook Reference) ; Aethosuccimidum ; Aethosuximide ; Aethosuximide [German] ; Asamid ; Atysmal ; C.I. 366 ; CI 366 ; CN-10,395 ; Capitus ; Emeside ; Epileo Petit MAL ; Ethosuccimide ; Ethosuccinimide ; Ethosuxide ; Ethosuximide ; Ethosuximidum ; Ethosuximidum [INN-Latin] ; Ethymal ; Etomal ; Etosuccimide ; Etosuccimide [DCIT] ; Etosuximid ; Etosuximida ; Etosuximida [INN-Spanish] ; Etosuximide ; H 940 ; H-490 ; HSDB 1119 ; Mesentol ; N-Ethyl methylsuccinimide ; NSC 64013 ; PM 671 ; Pemal ; Pemalin ; Pentinimid ; Peptinimid ; Petinimid ; Petnidan ; Piknolepsin ; Pyknolepsinum ; Ronton ; Simatin ; Simatin(E) ; Succimal ; Succimitin ; Succinimide, 2-ethyl-2-methyl- ; Suxilep ; Suximal ; Suxin ; Suxinutin ; Thetamid ; Thilopemal ; UNII-5SEH9X1D1D ; Zaraondan ; Zarodan ; Zarondan ; Zarondan-saft ; Zarontin ; Zartalin ; alpha-Ethyl-alpha-methylsuccinimide ; alpha-Methyl-alpha-ethylsuccinimide ; gamma-Methyl-gamma-ethyl-succinimide . It is a drug for treating absence seizures under the trade names Emeside and Zarontin due to the mechanism of action which is ethosuximide is a T-type calcium channel blocker with an IC₅₀ of 12 ± 2 mmol/L. Emeside capsules were discontinued by their manufacturer, Laboratories for Applied Biology, in 2005. Zarontin capsules were discontinued by Pfizer in 2007. Syrup preparations of both brands are still available.