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Curare (CAS NO.8063-06-7) can be extracted from Strychnos toxifera , Chondrodendron tomentosum .
Curare has been used historically as a paralyzing poison by South American indigenous people. Now it can be used as a non-depolarizing muscle relaxant that blocks the nicotinic acetylcholine receptor (nAChR). D-tubocurarine is the main toxin of curare which occupies the same position on the receptor as ACh with an equal affinity. Acetylcholinesterase (AChE) inhibitor can be used as the antidote for curare poisoning like physostigmine . AChE inhibitors can raise the amount of ACh in the neuromuscular junction by blocking ACh degradation.
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