| Identification | |
| Name: | CONCANAMYCIN A |
| Synonyms: | antibioticx4357b;x4357b;FOLIMYCIN;FOLIMYCIN, STREPTOMYCES SP;FOLIMYCIN, STREPTOMYCES SPECIES;CONCANAMYCIN A;CONCANAMYCIN A, STREPTOMYCES SP;concanamycin A from streptomyces species |
| CAS: | 80890-47-7 |
| Molecular Formula: | C46H75NO14 |
| Molecular Weight: | 866.09 |
| InChI: | InChI=1/C46H75NO14/c1-13-16-34-28(7)37(58-38-22-33(48)43(31(10)57-38)60-45(47)53)23-46(54,61-34)30(9)41(51)29(8)42-35(55-11)18-15-17-24(3)19-26(5)39(49)32(14-2)40(50)27(6)20-25(4)21-36(56-12)44(52)59-42/h13,15-18,20-21,26-35,37-43,48-51,54H,14,19,22-23H2,1-12H3,(H2,47,53)/b16-13+,18-15+,24-17+,25-20+,36-21-/t26-,27-,28-,29+,30+,31-,32+,33-,34-,35+,37-,38+,39+,40-,41-,42-,43-,46-/m1/s1 |
| Molecular Structure: |  |
| Properties | |
| Transport: | UN 3462 6.1/PG 2 |
| Flash Point: | 538.3°C |
| Boiling Point: | 966.4°C at 760 mmHg |
| Density: | 1.2g/cm3 |
| Refractive index: | 1.554 |
| Specification: | Safety Statements:26-36/37/39-45 26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 36/37/39:Wear suitable protective clothing, gloves and eye/face protection 45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) |
| Packinggroup: | III |
| Biological Activity: | Specific inhibitor of V-type (vacuolar) H + -ATPase that displays > 2000-fold selectivity over other H + -ATPases (IC 50 values are 9.2, > 20000, > 20000 and > 20000 nM for yeast V-type, F-type, P-type H + -ATPases and porcine P-type Na + ,K + -ATPase respectively). Blocks cell surface expression of virus envelope glycoproteins without affecting synthesis and exhibits cytotoxicity in several cell lines. |
| Flash Point: | 538.3°C |
| Storage Temperature: | −20°C |
| Safety Data | |
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