| Identification | |
| Name: | Cabergoline |
| Synonyms: | Ergoline-8-carboxamide,N-[3-(dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propenyl)-, (8b)- (9CI);Cabaser;Cabaseril;1-((6-Allylergolin-8beta-yl)carbonyl)-1-(3-(dimethylamino)propyl)-3-ethylurea;Ergoline-8beta-carboxamide, N-(3-(dimethylamino)propyl)-N-((ethylamino)carbonyl)-6-(2-propenyl)-; |
| CAS: | 81409-90-7 |
| Molecular Formula: | C26H37N5O2 |
| Molecular Weight: | 451.60428 |
| InChI: | InChI=1S/C26H37N5O2/c1-5-11-30-17-19(25(32)31(26(33)27-6-2)13-8-12-29(3)4)14-21-20-9-7-10-22-24(20)18(16-28-22)15-23(21)30/h5,7,9-10,16,19,21,23,28H,1,6,8,11-15,17H2,2-4H3,(H,27,33)/t19-,21-,23-/m1/s1 |
| Molecular Structure: | ![(C26H37N5O2) Ergoline-8-carboxamide,N-[3-(dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propenyl)-, (8b)- (...](https://img.guidechem.com/casimg/81409-90-7.gif) |
| Properties | |
| Density: | 1.156 g/cm3 |
| Refractive index: | 1.594 |
| Water Solubility: | Insoluble in water |
| Solubility: | Insoluble in water |
| Appearance: | White Crystalline Solid |
| Specification: |
? Cabergoline , with CAS number of 81409-90-7, can be called Ergoline-8-carboxamide,N-[3-(dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propenyl)-, (8b)- (9CI) ; Cabaser ; Cabaseril ; 1-((6-Allylergolin-8beta-yl)carbonyl)-1-(3-(dimethylamino)propyl)-3-ethylurea ; Ergoline-8beta-carboxamide, N-(3-(dimethylamino)propyl)-N-((ethylamino)carbonyl)-6-(2-propenyl)- . It is a white crystalline solid, used as a dopamine D2-receptor agonist.?It is frequently used as a second-line agent in the management of prolactinomas when bromocriptine is ineffective. |
| Biological Activity: | Selective D 2 -like dopamine receptor agonist (K i values are 0.7, 1.5, 9.0 and 165 nM for D 2 , D 3 , D 4 and D 5 receptors respectively) that also displays high affinity for several serotonin receptor subtypes (K i = 1.2-20.0 nM for 5-HT 1A , 5-HT 1D , 5-HT 2A and 5-HT 2B ). Inhibits secretion of prolactin and growth hormone and reverses levodopa-induced dyskinesias in Parkinsonian monkeys. |
| Usage: | A dopamine D2-receptor agonist. |
| Safety Data | |
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