| Identification | |
| Name: | vinblastine |
| Synonyms: | Vincaleukoblastine; |
| CAS: | 865-21-4 |
| EINECS: | 212-734-0 |
| Molecular Formula: | C46H58N4O9 |
| Molecular Weight: | 810.9856 |
| InChI: | InChI=1/C46H58N4O9/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3/t28-,37-,38+,39+,42-,43+,44+,45-,46-/m0/s1 |
| Molecular Structure: |  |
| Properties | |
| Transport: | 1544 |
| Melting Point: | 211 - 216 ºC |
| Density: | 1.37 g/cm3 |
| Solubility: | Practically insoluble in water, petroleum ether; soluble in alcohols, acetone, ethyl acetate, chloroform In water, 4.46X10-2 mg/L at 25 deg C (est) |
| Appearance: | POWDER |
| Specification: |
Vinblastine (865-21-4) is a vinca alkaloid and a chemical analogue of vincristine. It binds tubulin, thereby inhibiting the assembly of microtubules. It is M phase cell cycle specific since microtubules are a component of the mitotic spindle and the kinetochore which are necessary for the separation of chromosomes during anaphase of mitosis. |
| Report: |
NCI Carcinogenesis Studies (ipr); No Evidence: mouse CANCAR Cancer. 40 (1977),1935. ; (ipr); Clear Evidence: rat CANCAR Cancer. 40 (1977),1935. . EPA Genetic Toxicology Program. |
| Packinggroup: | II |
| Color: | Solvated needles from methanol |
| Safety Data | |
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