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1-[(5-CHLORO-1H-BENZIMIDAZOL-2-YL)CARBONYL]-4-METHYLPIPERAZINE MALEATE (869497-75-6)

Identification
Name:1-[(5-CHLORO-1H-BENZIMIDAZOL-2-YL)CARBONYL]-4-METHYLPIPERAZINE MALEATE
Synonyms:JNJ 10191584 MALEATE;1-[(5-CHLORO-1H-BENZIMIDAZOL-2-YL)CARBONYL]-4-METHYLPIPERAZINE MALEATE
CAS:869497-75-6
Molecular Formula: C17H19ClN4O5
Molecular Weight: 394.80956
Molecular Structure: (C17H19ClN4O5) JNJ 10191584 MALEATE;1-[(5-CHLORO-1H-BENZIMIDAZOL-2-YL)CARBONYL]-4-METHYLPIPERAZINE MALEATE
Properties
Flash Point: 232.6°C
Boiling Point: 461°C at 760 mmHg
Biological Activity: Highly selective histamine H 4 receptor silent antagonist; binds with high affinity to the human H 4 receptor (K i = 26 nM) and is > 540-fold selective over the H 3 receptor (K i = 14.1 μ M). In vitro, inhibits mast cell and eosinophil chemotaxis with IC 50 values of 138 and 530 nM respectively. Orally active in vivo .
Flash Point: 232.6°C
Storage Temperature: Desiccate at RT
Safety Data
 

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