| Identification |
| Name: | 2,10,12,16,18-Nonadecapentaenoicacid,19-[(2S,3S)-3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-,(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)- |
| Synonyms: | 2,10,12,16,18-Nonadecapentaenoicacid,19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-;Antibiotic CI 940; Antibiotic CL 1957A; CI 940; CL 1957A; Elactocin; LeptomycinB; Mantuamycin; NSC 364372; PD 114720 |
| CAS: | 87081-35-4 |
| Molecular Formula: | C33H48 O6 |
| Molecular Weight: | 540.73062 |
| InChI: | InChI=1S/C33H48O6/c1-9-28(14-15-29-24(5)13-16-31(36)39-29)19-22(3)12-10-11-21(2)17-25(6)32(37)27(8)33(38)26(7)18-23(4)20-30(34)35/h10-11,13-17,19-20,22,24-27,29,33,38H,9,12,18H2,1-8H3,(H,34,35)/b11-10+,15-14+,21-17+,23-20+,28-19-/t22-,24+,25-,26+,27-,29+,33-/m1/s1 |
| Molecular Structure: |
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| Properties |
| Transport: | UN 1230 3 |
| Melting Point: | 41-44 ºC |
| Density: | 1.072 g/cm3 |
| Refractive index: | 1.542 |
| Water Solubility: | soluble in ethanol, methanol |
| Solubility: | soluble in ethanol, methanol |
| Appearance: | White crystalline solid. |
| Biological Activity: | Antifungal antibiotic that is an inhibitor of the nuclear export of proteins; acts by binding directly to and inhibiting CRM1/exportin-1. Inhibits the nuclear export of the HIV regulatory protein Rev and stabilizes p53. Antitumor in vitro and in vivo . |
| Storage Temperature: | −20°C |
| Safety Data |
| Hazard Symbols |
T: Toxic
F: Flammable
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