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EMEDASTINE DIFUMARATE (87233-62-3)

Identification
Name:EMEDASTINE DIFUMARATE
Synonyms:1-(2-Ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)benzimidazole difumarate;Emedastinum [INN-Latin];1H-Benzimidazole, 1-(2-ethoxyethyl)-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-;KB 2413;87233-61-2;Emedastine [INN];1-(2-ethoxyethyl)-2-(4-methyl-1,4-diazepan-1-yl)benzoimidazole;1H-Benzimidazole, 1-(2-ethoxyethyl)-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-, (E)-2-butenedioate (1:2);Daren;1H-Benzimidazole,1-(2-ethoxyethyl)-2- (hexahydro-4-methyl-1H-1,4-diazepin-1- yl)-,(2E)-2-butenedioate (1:2);1-(2-Ethoxyethyl)-2-(4-methylhexahydro-1H-1,4-diazepin-1-yl)benzimidazole fumarate (1:2);Emedastine;Benzimidazole, 1-(2-ethoxyethyl)-2-(4-methylhexahydro-1H-1,4-diazepin-1-yl)-, fumarate (1:2);AL 3432A;Daren (TN);Rapimine;1-(2-Ethoxyethyl)-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)benzimidazole;LY 188695;Emadine (TN);KB-2413;KG-2413;but-2-enedioic acid; 1-(2-ethoxyethyl)-2-(4-methyl-1,4-diazepan-1-yl)benzoimidazole;Emedastine difumarate (JAN/USP);Emadine;1-Methyl-4-(1-(2-ethoxyethyl)-1H-benzimidazo)-2-yl)(1,4)diazepane;Emedastine Difumarate [USAN];KG 2413;Emedastina [INN-Spanish];1H-BENZIMIDAZOLE, 1-(2-ETHOXYETHYL)-2-(HEXAHYDRO-4-METHYL-1H-1,4-DIAZEPIN-1-YL)-,(E)-2-BUTENEDIOATE (1:2);BENZIMIDAZOLE,-1-(2-ETHOXYETHYL)-2-(4-METHYLHEXAHYDRO-1H-1,4-DIAZEPIN-1-YL)-, FUMARATE (1:2);1-(2-ETHOXYETHYL)-2-(4-METHYL-1-HOMOPIPERAZINYL)-BENZIMIDAZOLE DIFUMARATE;
CAS:87233-62-3
Molecular Formula: C17H26N4O•2C4H4O4
Molecular Weight: 534.63
InChI: InChI=1/C17H26N4O.2C4H4O4/c1-3-22-14-13-21-16-8-5-4-7-15(16)18-17(21)20-10-6-9-19(2)11-12-20;2*5-3(6)1-2-4(7)8/h4-5,7-8H,3,6,9-14H2,1-2H3;2*1-2H,(H,5,6)(H,7,8)/b;2*2-1+
Molecular Structure: (C17H26N4O•2C4H4O4) 1-(2-Ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)benzimidazole difumarate;Emedastinum [INN-Latin];1H-...
Properties
Flash Point: 446.6 ºC at 760 mmHg
Boiling Point: 446.6 ºC at 760 mmHg
Specification:

 Emedastine Difumarate (CAS NO.87233-62-3) is has IUPAC Name of (E)-but-2-enedioic acid;1-(2-ethoxyethyl)-2-(4-methyl-1,4-diazepan-1-yl)benzimidazole and it is also called 1-(2-Ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)benzimidazole difumarate ; 1-(2-Ethoxyethyl)-2-(4-methylhexahydro-1H-1,4-diazepin-1-yl)benzimidazole fumarate (1:2)
1-(2-Ethoxyethyl)-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)benzimidazole fumarate (1:2) ; 1H-Benzimidazole, 1-(2-ethoxyethyl)-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-, (E)-2-butenedioate (1:2) ; AL 3432A ; Benzimidazole, 1-(2-ethoxyethyl)-2-(4-methylhexahydro-1H-1,4-diazepin-1-yl)-, fumarate (1:2) ; KB-2413 ; LY 188695 ; Rapimine ; UNII-42MB94QOSM ; emadine .
  Emedastine Difumarate (CAS NO.87233-62-3) is an antihistamine used in eye drops to treat allergic conjunctivitis. It is one kind of dangerous material, a poison by ingestion and intravenous routes. Moderately toxic by subcutaneous route. When heated to decomposition it emits toxic vapors of NOx. And its toxic tabulation is:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral 193mg/kg (193mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP		 Oyo Yakuri. Pharmacometrics. Vol. 39, Pg. 209, 1990.
guinea pig LD50 oral 744mg/kg (744mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 34, Pg. 801, 1984.
mouse LD50 intravenous 93mg/kg (93mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Oyo Yakuri. Pharmacometrics. Vol. 39, Pg. 209, 1990.
mouse LD50 oral 628mg/kg (628mg/kg)   United States Patent Document. Vol. #4430343,
mouse LD50 subcutaneous 609mg/kg (609mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Oyo Yakuri. Pharmacometrics. Vol. 39, Pg. 209, 1990.
rat LD50 intravenous 72mg/kg (72mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Oyo Yakuri. Pharmacometrics. Vol. 39, Pg. 209, 1990.
rat LD50 oral 1854mg/kg (1854mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Oyo Yakuri. Pharmacometrics. Vol. 39, Pg. 209, 1990.
rat LD50 subcutaneous 643mg/kg (643mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Oyo Yakuri. Pharmacometrics. Vol. 39, Pg. 209, 1990.

Flash Point: 446.6 ºC at 760 mmHg
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