Oxacyclohexadeca-3,5,11,13-tetraen-2-one,8-hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyl-,(3Z,5E,7R,8S,9S,11E,13E,15S,16R)- (88899-55-2)

Identification
Name:	Oxacyclohexadeca-3,5,11,13-tetraen-2-one,8-hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyl-,(3Z,5E,7R,8S,9S,11E,13E,15S,16R)-
Synonyms:	Hygrolidin,21-O-de(3-carboxy-1-oxo-2-propenyl)-2-demethyl-2-methoxy-24-methyl-;Oxacyclohexadecane, hygrolidin deriv.; (-)-Bafilomycin A1; Bafilomycin A1; NSC381866; Oxacyclohexadeca-3,5,11,13-tetraen-2-one,8-hydroxy-16-[2-hydroxy-1-methyl-3-[tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyl-,[7R-[3Z,5E,7R,8S,9S,11E,13E,15S,16R[1S,2R,3S(2R,4R,5S,6R)]]]-
CAS:	88899-55-2
Molecular Formula:	C35H58 O9
Molecular Weight:	622.8296
InChI:	InChI=1/C35H58O9/c1-19(2)32-24(7)27(36)18-35(40,44-32)26(9)31(38)25(8)33-28(41-10)14-12-13-20(3)15-22(5)30(37)23(6)16-21(4)17-29(42-11)34(39)43-33/h12-14,16-17,19,22-28,30-33,36-38,40H,15,18H2,1-11H3/b14-12+,20-13+,21-16+,29-17-/t22-,23+,24-,25-,26-,27+,28-,30-,31+,32+,33+,35+/m0/s1
Molecular Structure:
Properties
Transport:	3172
Density:	1.12 g/cm³
Refractive index:	1.534
Packinggroup:	III
Biological Activity:	Highly potent, selective inhibitor of vacuolar H + -ATPases (IC 50 = 500 pM as measured in chromaffin granule membranes). Selective over other ATP hydrolyzing enzymes such as F-ATPases, Ca 2+ -ATPases, Na + /K + -ATPases and plasma membrane H + -ATPases.
Storage Temperature:	2-8°C
Safety Data
Hazard Symbols	Xi: Irritant

Oxacyclohexadeca-3,5,11,13-tetraen-2-one,8-hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyl-,(3Z,5E,7R,8S,9S,11E,13E,15S,16R)- (88899-55-2)

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