Ethanone,2-[(2R,6S)-6-[(2S)-2-hydroxy-2-phenylethyl]-1-methyl-2-piperidinyl]-1-phenyl- (90-69-7)

Identification
Name:	Ethanone,2-[(2R,6S)-6-[(2S)-2-hydroxy-2-phenylethyl]-1-methyl-2-piperidinyl]-1-phenyl-
Synonyms:	Ethanone,2-[6-(2-hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl]-1-phenyl-, [2R-[2a,6a(S*)]]-; Lobeline (8CI); a-Lobeline (7CI); (-)-Lobeline; (-)-a-Lobeline; 2-[6-(b-Hydroxyphenethyl)-1-methyl-2-piperidyl]acetophenone;8,10-Diphenyllobelionol; Inflatine; L-Lobeline; Lobelin; Lobnico; NIH 11034;l-Lobeline
CAS:	90-69-7
EINECS:	202-012-3
Molecular Formula:	C22H27 N O2
Molecular Weight:	337.46
InChI:	InChI=1/C22H27NO2/c1-23-19(15-21(24)17-9-4-2-5-10-17)13-8-14-20(23)16-22(25)18-11-6-3-7-12-18/h2-7,9-12,19-21,24H,8,13-16H2,1H3
Molecular Structure:
Properties
Transport:	1544
Flash Point:	247.5°C
Boiling Point:	485.6°C at 760 mmHg
Density:	1.085g/cm³
Refractive index:	1.562
Specification:	Lobeline (CAS NO.90-69-7) is a highly-toxic material,Iis pure form is a white amorphous powder which is freely soluble in water.burning will produce nitrogen oxides emitted toxic fumes.Besides should be stored and transported in low-temperature,drying environment. separately with oxidizing agents.Fire extinguishing agents water, carbon dioxide, dry powder, foam would be used if emergency. Lobeline (CAS NO.90-69-7) has been used as a smoking cessation aid, and may have application in the treatment of other drug addictions such as addiction to amphetamines, cocaine or alcohol..Lobeline has multiple mechanisms of action, acting as a VMAT2 ligand, which stimulates dopamine release to a moderate extent when administered alone, but reduces the dopamine release caused by methamphetamine. It also inhibits the reuptake of dopamine and serotonin, and acts as a mixed agonist-antagonist at nicotinic acetylcholine receptors and an antagonist at μ-opioid receptors.
Packinggroup:	III
Flash Point:	247.5°C
Safety Data

Ethanone,2-[(2R,6S)-6-[(2S)-2-hydroxy-2-phenylethyl]-1-methyl-2-piperidinyl]-1-phenyl- (90-69-7)

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