Specification: |
The systematic name of Rizolipase is Lipase of Rhizopus arrhizus var. Delemar. With the CAS registry number 9001-62-1, it is also named as Accelerase. The product's categories are Hydrolases; Specialty Enzymes; Enzyme Class Index; Others; HydrolasesEnzyme Class Index; Novozymes: Quality Environmentally-Friendly EnzymesEnzyme Class Index; Analytical Enzymes; Diagnostic and Analytical EnzymesApplication Index; 3.1.x.x Acting on esters; 3.x.x.x Hydrolases; Application Index; Enzymes, Inhibitors, and Substrates; Organic Synthesis and Immobilized Enzymes; Organic SynthesisEnzyme Class Index; Enzyme-Mediated Synthesis; Specialty Synthesis; Diagnostic and Analytical EnzymesSpecialty Synthesis; HydrolasesApplication Index, and the other registry numbers are 119663-46-6; 132823-04-2; 135105-44-1; 142615-72-3; 211049-96-6; 211049-97-7; 211255-77-5; 212955-16-3; 9001-70-1; 9004-01-7; 9014-49-7. Besides, it is yellow-brown solution, which was soluble in water and hazy with insoluble particles. But it is moisture sensitive and incompatible with strong oxidizing agents. In addition, this chemical should be sealed in brown glass bottle which was stored in dry place below 4 °C.
Preparation of Rizolipase: this chemical is prepared by pig pancreas. Please degrease 3 kg pig pancreas which was triturated by Chloroform and Butanol. And then you should extract it by Ethanol. Finally, please freeze drying it to get 365 g Rizolipase.
Uses of Rizolipase: it is used as enzyme preparation. And it is mainly used for producing of cheese, lipid modification and hydrolysis to prevent alteration of fat in some dairy products and chocolate. Additionally, the product is a lipase of mycete which is used for washing of clothes, industry and utensils.
When you are using this chemical, please be cautious about it as the following: it is harmful by inhalation, in contact with skin and if swallowed. You should wear suitable protective clothing and gloves to avoid contact with skin and eyes. Moreover, please do not breathe dust.
The toxicity data is as follows:
Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
guinea pig |
LD50 |
intravenous |
135mg/kg (135mg/kg) |
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
KIDNEY, URETER, AND BLADDER: OTHER CHANGES |
Pharmaceutical Chemistry Journal Vol. 13, Pg. 906, 1979. |
mouse |
LD |
oral |
> 10400mg/kg (10400mg/kg) |
|
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 69, Pg. 191, 1973. |
mouse |
LD50 |
intraperitoneal |
395mg/kg (395mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
SKIN AND APPENDAGES (SKIN): HAIR: OTHER |
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 69, Pg. 191, 1973. |
mouse |
LD50 |
intraperitoneal |
833mg/kg (833mg/kg) |
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
BLOOD: HEMORRHAGE |
Pharmaceutical Chemistry Journal Vol. 13, Pg. 906, 1979. |
mouse |
LD50 |
intravenous |
127mg/kg (127mg/kg) |
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
KIDNEY, URETER, AND BLADDER: OTHER CHANGES |
Pharmaceutical Chemistry Journal Vol. 13, Pg. 906, 1979. |
mouse |
LD50 |
subcutaneous |
2050mg/kg (2050mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
SKIN AND APPENDAGES (SKIN): HAIR: OTHER |
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 69, Pg. 191, 1973. |
rabbit |
LD |
oral |
> 5gm/kg (5000mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
SKIN AND APPENDAGES (SKIN): HAIR: OTHER |
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 69, Pg. 191, 1973. |
rat |
LD |
oral |
> 10400mg/kg (10400mg/kg) |
|
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 69, Pg. 191, 1973. |
rat |
LD |
subcutaneous |
> 5gm/kg (5000mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
SKIN AND APPENDAGES (SKIN): HAIR: OTHER
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) |
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 69, Pg. 191, 1973. |
rat |
LD50 |
intraperitoneal |
630mg/kg (630mg/kg) |
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
BLOOD: HEMORRHAGE |
Pharmaceutical Chemistry Journal Vol. 13, Pg. 906, 1979. |
rat |
LD50 |
intraperitoneal |
634mg/kg (634mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
SKIN AND APPENDAGES (SKIN): HAIR: OTHER |
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 69, Pg. 191, 1973. |
rat |
LD50 |
intravenous |
104mg/kg (104mg/kg) |
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
KIDNEY, URETER, AND BLADDER: OTHER CHANGES |
Pharmaceutical Chemistry Journal Vol. 13, Pg. 906, 1979. |
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