| Identification |
| Name: | Pyridine,2-methyl-6-(2-phenylethynyl)- |
| Synonyms: | 2-Picoline,6-phenylethynyl- (6CI); Pyridine, 2-methyl-6-(phenylethynyl)- (9CI);2-Methyl-6-(phenylethynyl)pyridine; MPEP |
| CAS: | 96206-92-7 |
| Molecular Formula: | C14H11 N |
| Molecular Weight: | 229.7 |
| InChI: | InChI=1/C14H11N.ClH/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13;/h2-9H,1H3;1H |
| Molecular Structure: |
 |
| Properties |
| Flash Point: | 144.8°C |
| Boiling Point: | 336.3°Cat760mmHg |
| Density: | g/cm3 |
| Biological Activity: | Potent and highly selective non-competitive antagonist at the mGlu 5 receptor subtype (IC 50 = 36 nM) and a positive allosteric modulator at mGlu 4 receptors. Centrally active following systemic administration in vivo . Reverses mechanical hyperalgesia in the inflamed rat hind paw. Also available as part of the Group I mGlu Receptor Tocriset™ . |
| Flash Point: | 144.8°C |
| Usage: | A potent, subtype selective mGluR5 antagonist |
| Safety Data |
| |
 |
