9,12-Epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylicacid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester,(9S,10R,12R)- (99533-80-9)

Identification
Name:	9,12-Epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylicacid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester,(9S,10R,12R)-
Synonyms:	9,12-Epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylicacid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester, [9S-(9a,10b,12a)]-; (+)-Antibiotic K 252a; (+)-Antibiotic SF 2370; (+)-K 252a; (+)-SF2370; Antibiotic K 252a; Antibiotic K 252a, (+)-; Antibiotic SF 2370;Antibiotic SF 2370, (+)-; K 252a; Protein kinase inhibitor K252a; SF 2370
CAS:	99533-80-9
Molecular Formula:	C27H21 N3 O5
Molecular Weight:	467.47
InChI:	InChI=1/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18-,26+,27+/m1/s1
Molecular Structure:
Properties
Flash Point:	368.2°C
Boiling Point:	685.3°Cat760mmHg
Density:	1.67g/cm³
Refractive index:	1.841
Biological Activity:	Non-selective protein kinase inhibitor; analog of staurosporine. Inhibits PKC (IC 50 = 32.9 nM), Ca 2+ /calmodulin-stimulated phosphodiesterases (IC 50 = 1.3-2.9 μ M), MLCK (K i = 20 nM) and receptor tyrosine kinases. Inhibits the oncogenic properties of MET; prevents autophosphorylation and activation of downstream effectors (MAPK, Akt).
Flash Point:	368.2°C
Storage Temperature:	−20°C
Safety Data
Hazard Symbols	Xi: Irritant