| [Flash Point] 228 | |
| [Fire Fighting] Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. | |
| [Fire Potential] This material is probably combustible. | |
| [Ingestion] Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. | |
| [Inhalation] Remove from exposure to fresh air immediately. | |
| [Skin] Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. | |
| [Eyes] Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. | |
| [Storage] Store in a cool, dry place. Keep container closed when not in use. Hormones and antibiotics room. | |
| [Handling] Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation. | |
| [Inhalation] Symptoms of exposure to this compound may include urticaria, headaches, confusion, dizziness, nausea, diarrhea, photosensitivity and leukopenia. Other symptoms may include epigastric distress, fever and arthralgia. It may cause renal damage and porphyria. It may also cause peripheral neuritis, syncope and blurred vision. Exposure has caused skin rashes, fatigue, proteinuria and, rarely, angioneurotic edema, paresthesia and lupus erythematosus. Symptoms may include dryness of the mouth, an altered sensation of taste, gastrointestinal disturbances, severe allergic reactions, erythema multiforme, exfoliative dermatitis, candidiasis, depression, irritability and, rarely, hepatitis. | |
| [Skin] See inhalation. | |
| [Eyes] See inhalation | |
| [Ingestion] See inhalation. | |
| [Personal Protection] Eyes: Wear safety glasses and chemical goggles if splashing is possible. Skin: Wear appropriate protective gloves and clothing to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin. | |
| [Respirators] Wear a NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline respirator in the positive pressure mode with emergency escape provisions. | |
| [Exposure Effects] headache, dizziness, disorientation, lethargy, fatigue, and mental confusion may be noted. Paresthesia secondary to peripheral neuropathy has been reported following therapeutic use. Use in pregnancy is contraindicated. Griseofulvin is classified as FDA pregnancy category C. There is no data concerning breast milk. | |
| [Exposure limit(s)] OSHA: Possible Select carcinogen | |
| [Appearance] White to pale cream-colored crystalline powder. Odorless or almost odorless. Tasteless. | |
| [Solubility in water] Insoluble | |
| [Melting Point] 218 - 222 | |
| [Boiling Point] 570 | |
| [Vapor Pressure] 5E-13 (25 C) | |
| [Density] 1.4 g/cm3 | |
| [Partition Coefficient] 2.36 | |
| [Heat Of Vaporization] 85.6 kJ/mol | |
| [Usage] Medication, fungicide. | |
| [Product Name] (+)-Griseofulvin | |
| [Synonyms] 7-Chloro-2',4,6-trimethoxy-6'b-methylspiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione Amudane Fulvistatin Polygris Sporostatin Xuanjing | |
| [CAS] "CASEN_126-07-8.htm">126-07-8 | |
| [Formula] C17H17ClO6 | |
| [Molecular Weight] 352.77 | |
| [EINECS] 204-767-4 | |
| [RTECS] WG9800000 | |
| [RTECS Class] Agricultural Chemical and Pesticide; Tumorigen; Drug; Mutagen; Reproductive Effector; Natural Product | |
| [Merck] 12,4571 | |
| [Beilstein/Gmelin] 95226 | |
| [Beilstein Reference] 5-18-05-00150 | |
| [Small spills/leaks] Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. | |
| [Stability] Stable under normal temperatures and pressures. | |
| [Incompatibilities] Strong oxidizing agents. | |
| [Decomposition] Hydrogen chloride, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide. |
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