| [Fire Fighting] Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam. | |
| [Fire Potential] This material is probably combustible. | |
| [Ingestion] If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid. | |
| [Inhalation] Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms appear. | |
| [Skin] Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. | |
| [Eyes] Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. | |
| [Storage] Store in a cool, dry, well-ventilated area away from incompatible substances. Keep containers tightly closed. | |
| [Handling] Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation. | |
| [Inhalation] Inhalation of dust may cause respiratory tract irritation. | |
| [Skin] May cause skin irritation. May cause dermatitis. | |
| [Eyes] May cause eye irritation. | |
| [Ingestion] May cause bone marrow depression. Ingestion of large amounts may cause nausea and vomiting, which can produce dehydration, internal organ congestion and possibly coma. May cause microcytosis (smaller than normal red blood cells), normocytic anemia (reduced red blood cell count), luekopenia(reduced white blood cell count), thrombocytopenia (decreased number of blood platelets) and other blood abnormalities. | |
| [EC Risk Phrase] R 46 61 | |
| [EC Safety Phrase] S 53 45 | |
| [UN (DOT)] 2811 | |
| [Personal Protection] Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. | |
| [Respirators] Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary. | |
| [Exposure Effects] Hydroxyurea crosses the placenta in animals, and is embryotoxic. | |
| [Poison Class] 1* | |
| [Appearance] Odorless or almost odorless white to off-white crystalline solid. Tasteless. | |
| [Solubility in water] Soluble | |
| [Melting Point] 142 - 144 | |
| [Boiling Point] 296 | |
| [Partition Coefficient] -1.8 | |
| [Usage] Medication. | |
| [Product Name] Hydroxyurea | |
| [Synonyms] Hydroxycarbamide | |
| [CAS] "CASEN_127-07-1.htm">127-07-1 | |
| [Formula] CH4N2O2 | |
| [Molecular Weight] 76.06 | |
| [EINECS] 204-821-7 | |
| [RTECS] YT4900000 | |
| [RTECS Class] Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data; Primary Irritant | |
| [Merck] 13,4874 | |
| [Beilstein/Gmelin] 1741548 | |
| [Beilstein Reference] 4-03-00-00170 | |
| [Small spills/leaks] Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation. | |
| [Stability] Stable under normal temperatures and pressures. | |
| [Incompatibilities] Strong oxidizing agents. | |
| [Decomposition] Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen. | |
| [UN Number] 2811 |
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