| [Flash Point] 82 | |
| [Autoignition] 570 | |
| [Fire Fighting] Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire. | |
| [Fire Fighting] Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Combustible Liquid. Containers may explode when heated. Extinguishing media: Use water spray to cool fire-exposed containers. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam. | |
| [Upper exp. limit] 5.2 | |
| [Lower exp. limit] 1.4 | |
| [Fire Potential] Slight when exposed to head or flame. | |
| [Ingestion] Induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid. | |
| [Ingestion] May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure. May be harmful if swallowed. | |
| [Ingestion] Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended. | |
| [Inhalation] Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. | |
| [Inhalation] Inhalation of high concentrations may cause central nervous system effects characterized by headache, dizziness, unconsciousness and coma. Material has a low vapor pressure, so exposure to vapor is not likely. | |
| [Inhalation] If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention. | |
| [Skin] Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. | |
| [Skin] Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. | |
| [Skin] Causes skin irritation. | |
| [Eyes] May cause transient corneal injury. Causes severe eye irritation and possible injury. | |
| [Eyes] Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. | |
| [Eyes] Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility. | |
| [Storage] Keep away from heat and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. | |
| [Storage] Store below 40C (104F), preferably between 15 and 30C (59 and 86F), unless otherwise specified by manufacturer. Store in a well-closed container. | |
| [Handling] Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Use spark-proof tools and explosion proof equipment. Avoid contact with skin and eyes. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Avoid contact with heat, sparks and flame. Avoid ingestion and inhalation. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. | |
| [Handling] All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood. | |
| [Inhalation] Pneumonitis, chest tightness, and wheezing have been reported. | |
| [Skin] Skin may be flushed, warm and dry after overdose. | |
| [Eyes] Anticholinergic effects, such as prolonged dialation of the pupils, nasal dryness and stuffiness, and mouth and throat dryness, can occur with overdose or therapeutic use. | |
| [Ingestion] Overdose may cause anticholinergic effects of ileus and diminished bowel sounds. Nausea, vomiting, and loss of appetite may occur . | |
| [Hazards] Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. | |
| [EC Risk Phrase] R 22 36 | |
| [EC Safety Phrase] S 26 | |
| [UN (DOT)] 1993 | |
| [Personal Protection] Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots. | |
| [Personal Protection] Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin. | |
| [Respirators] A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use. | |
| [Respirators] Use NIOSH/MSHA approved respirator appropriate for exposure of concern. | |
| [Exposure Effects] Prolonged or repeated eye contact may cause conjunctivitis. Prolonged or repeated skin contact may cause defatting and dermatitis. Laboratory experiments have resulted in mutagenic effects. Narcotic in high concentrations. | |
| [Exposure Effects] Rapid heart rate is common. Elevated body temperature, abnormally low blood pressure, and elevated blood pressure have been reported. overdose may result in either CNS depression, including coma, or CNS stimulation, such as toxic psychosis. Subsequent seizures are not uncommon, especially in children. A higher incidence of seizures has been reported following pheniramine overdoses. Therapeutic use has been associated with acute dystonic reactions and dyskinesias. In general, there have been few reported teratogenic effects in humans, although animal studies have suggested that certain antihistamines have teratogenic potential. <br>Pyloric stenosis has occurred in infants following maternal use of antihistamines. <br>Small amounts of antihistamines are excreted in breast milk. | |
| [Exposure limit(s)] TLV: 10 ppm; 49 mg/m3 (ACGIH 1993-1994). | |
| [Poison Class] 4 | |
| [Appearance] Colorless liquid, sweet, almond odor. | |
| [Appearance] Crystals from dil ethanol. | |
| [Solubility in water] 5.5 g/L | |
| [Solubility in water] Insoluble | |
| [Melting Point] 116.5 - 118 | |
| [Melting Point] 20 | |
| [Boiling Point] 201.7 | |
| [Vapor Pressure] 0.3 (25 C) | |
| [Density] 1.027 g/cm3 (20 C) | |
| [pKa/pKb] 5.30 (pKb) | |
| [Partition Coefficient] 1.58 | |
| [Heat Of Vaporization] 49.0 kJ/mol | |
| [Usage] Medication. | |
| [Usage] In perfumery to impart an orange-blossom-like odor, catalyst for polymerization of olefins, in organic synthesis, esp as photosensitizer. | |
| [Saturation Concentration] Approximately 1300 ppm (0.13%) at 20 C (calculated) | |
| [Odor threshold] 0.01-0.025 mg/m3 | |
| [Refractive Index] 1.5339 (20 C) | |
| [Product Name] Cyproheptadine | |
| [Synonyms] 1-Methyl-4-(5H-dibenzo[a,d]cycloheptenylidene)piperidine 1-Methyl-4-(dibenzo[a,e]cycloheptatrien-5-ylidene)piperidine 1-Phenylethanone 4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine Acetylbenzene Cyproheptadine Methyl phenyl ketone Phenyl methyl ketone Piperidine, 4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-methyl- | |
| [CAS] "CASEN_129-03-3.htm">129-03-3 | |
| [CAS] "CASEN_98-86-2.htm">98-86-2 | |
| [Formula] C21H21N | |
| [Formula] C8H8O | |
| [Molecular Weight] 120.15 | |
| [Molecular Weight] 287.39999999999998 | |
| [EINECS] 202-708-7 | |
| [EINECS] 204-928-9 | |
| [RTECS] AM5250000 | |
| [RTECS] TM7000000 | |
| [RTECS Class] Mutagen; Primary Irritant | |
| [RTECS Class] Drug; Mutagen; Reproductive Effector | |
| [Merck] 12,2842 | |
| [Merck] 13,74 | |
| [Beilstein/Gmelin] 1685976 | |
| [Beilstein/Gmelin] 605842 | |
| [Beilstein Reference] 4-07-00-00619 | |
| [Beilstein Reference] 5-20-08-00500 | |
| [EC Index Number] 606-042-00-1 | |
| [EC Class] Harmful; Irritant | |
| [Small spills/leaks] Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Clean up spills immediately, using the appropriate protective equipment. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation. | |
| [Small spills/leaks] Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces. | |
| [Stability] Relatively stable in light, stable @ room temperature. | |
| [Stability] Stable under normal temperatures and pressures. | |
| [Incompatibilities] Strong oxidizing agents, strong bases, strong reducing agents, aldehydes, nitric acid + hydrogen peroxide, perchloric acid. | |
| [Incompatibilities] Strong oxidizing agents. | |
| [Disposal Code] 3 | |
| [Decomposition] Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide. | |
| [Combustion Products] Fire may produce irritating, corrosive and/or toxic gases. | |
| [UN Number] 1993 | |
| [Hazard Class] 3 | |
| [Packing Group] I; II; III | |
| [HS Code] 2914 39 00 |
Print