| [Fire Fighting] Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire. | |
| [Ingestion] Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended. | |
| [Inhalation] If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention. | |
| [Skin] Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse. | |
| [Eyes] If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention. | |
| [Storage] Pancuronium bromide should be stored under refrigeration at 2-8C. Keep container tightly closed. | |
| [Handling] When protective clothing and respirator when handling this material. | |
| [Inhalation] Prolonged apnea and respiratory arrest may be noted due to paralysis of the intercostal muscles and diaphragm. | |
| [Skin] Absorbed through wonds and skin defects. Paralysis with risk of respiratory failure. | |
| [Ingestion] Prolonged apnea and respiratory arrest may be noted due to paralysis of the intercostal muscles and diaphragm. | |
| [Personal Protection] Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant (rubber) gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots. | |
| [Respirators] A supplied (purified) air respirator, hood fit type, breathable air via hose. | |
| [Exposure Effects] paralysis of skeletal muscle results in heaviness of the eyelids, difficulty in swallowing and talking, diplopia, progressive weakness of the extremities, the neck, intercostals and diaphragm. Tubocurarine does not penetrate the blood brain barrier hence few CNS effects are noted. | |
| [Appearance] White to near-white, hydroscopic crystalline powder with no odor. | |
| [Melting Point] 214 - 217 | |
| [Usage] Medication. | |
| [Product Name] Pancuronium bromide | |
| [Synonyms] 2b,16b-Dipiperidino-5a-androstane-3a,17b-diol diacetate dimethobromide Mioblock Pavulon Piperidinium, 1,1'-[(2b,3a,5a,16b,17b)-3,17-bis(acetyloxy)androstane-2,16-diyl]bis[1-methyl-, dibromide | |
| [CAS] "CASEN_15500-66-0.htm">15500-66-0 | |
| [Formula] C35H60Br2N2O4 | |
| [Molecular Weight] 732.68 | |
| [EINECS] 239-532-5 | |
| [RTECS] TN4930000 | |
| [RTECS Class] Drug; Mutagen; Reproductive Effector; Human Data | |
| [Merck] 12,7139 | |
| [Beilstein/Gmelin] 4121757 | |
| [Beilstein Reference] 5-20-03-00259 | |
| [Small spills/leaks] Sweep up carefully and transfer to a container and tightly seal. Wear protective equipment. | |
| [Stability] Stable at normal temperatures and pressures. | |
| [Incompatibilities] Strong oxidizing agents. | |
| [Decomposition] Hydrogen bromide. |
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