| [Fire Fighting] Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire. | |
| [Ingestion] Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended. | |
| [Inhalation] If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention. | |
| [Skin] Remove contaminated clothing and wash exposed area thoroughly with soap and water. A physician should examine the area if irritation or pain persists. | |
| [Eyes] Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility. | |
| [Storage] Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. | |
| [Handling] Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation. Wash clothing before reuse. | |
| [Inhalation] Causes respiratory tract irritation. May cause allergic respiratory tract irritation. Can produce delayed pulmonary edema. | |
| [Skin] Doxorubicin has irritant properties. Severe ulceration and necrosis may occur from extravasation. | |
| [Eyes] Causes eye irritation. May cause chemical conjunctivitis. | |
| [Ingestion] Nausea, vomiting, and diarrhea may occur. | |
| [Personal Protection] Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots. | |
| [Respirators] Respiratory protection should be an adjunct to and not a substitute for engineering controls.<BR>Organic vapor acid gas canister; done in the open, an area away from drafts and traffic | |
| [Exposure Effects] Prolonged or repeated exposure may cause adverse reproductive effects. Repeated exposure may cause allergic respiratory reaction (asthma). Effects may be delayed. May cause allergic skin reaction in some individuals. | |
| [Appearance] Orange powder. | |
| [Solubility in water] 2% | |
| [Melting Point] 216 | |
| [pKa/pKb] 8.33 (pKa) | |
| [Usage] Medication. | |
| [Product Name] (1S,3S)-3,5,12-Trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside | |
| [Synonyms] (85-Cis)-10-Tetrahydro-6,8,11-Trihydroxy-8-(Hydroxyacetyl)-1-methoxy-5,12-Naphthacenedione (8S)-10-((4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yloxy)-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione ADM Adriamycin Adriblastin Adriblastina | |
| [CAS] "CASEN_23214-92-8.htm">23214-92-8 | |
| [Formula] C27H29NO11 | |
| [Molecular Weight] 543.53 | |
| [EINECS] 245-495-6 | |
| [RTECS] AV9800000 | |
| [RTECS Class] Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data; Natural Product; Primary Irritant | |
| [Merck] 12,3495 | |
| [Beilstein/Gmelin] 1445811 | |
| [Small spills/leaks] Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately. Avoid generating dusty conditions. Provide ventilation. | |
| [Stability] Stable at room temperature in closed containers under normal storage and handling conditions. | |
| [Incompatibilities] Strong oxidizing agents. | |
| [Decomposition] Hydrogen chloride, nitrogen oxides, carbon monoxide, carbon dioxide. |
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