| [Fire Fighting] Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire. | |
| [Ingestion] Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended. | |
| [Inhalation] If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention. | |
| [Skin] Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. | |
| [Eyes] If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention. | |
| [Storage] Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage. | |
| [Handling] All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood. | |
| [Inhalation] Although rare, respiratory arrest has been reported. Pulmonary fibrosis has been associated . | |
| [Skin] Photosensitivity, toxic epidermal necrolysis, erythema multiforme, and phototoxicity have been reported . | |
| [Eyes] Various ocular adverse reactions and tinnitus are frequently reported following NSAID overdoses. Bullous and erosive stomatitis has occurred in a patient taking nimesulide and diclofenac. | |
| [Ingestion] Nausea, vomiting, epigastric pain, erosive esophagitis, pancreatitis, gastrointestinal bleeding, and intestinal stenosis have been associated and/or overdose of non-steroidal antiinflammatory drugs. | |
| [Personal Protection] Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots. | |
| [Respirators] Use NIOSH/MSHA approved respirator appropriate for exposure of concern. | |
| [Exposure Effects] Low grade fever, abnormally low blood pressure, and sinus rapid heart rate have been noted in both overdose and therapeutic use of nsaids. drowsiness, delirium, lethargy, seizures, dizziness, disorientation, loss of consciousness, tinnitus, headache, hallucinations and encephalopathy have been associated with therapeutic dosing and/or overdose of non-steroidal anti-inflammatory drugs. Coma has been reported following severe nsaid overdose. Myoclonic twitching as been reported for several days after an overdose of piroxicam and fentiazac. Use in pregnancy is not recommended. Inhibition of prostaglandin synthesis may cause closure of the ductus arteriosus. NSAIDs may prolong pregnancy if taken before the onset of labor, especially during the third trimester. | |
| [Appearance] Crystals from acetonitrile. | |
| [Solubility in water] Soluble | |
| [Melting Point] 191 | |
| [pKa/pKb] 4.46 (pKa) | |
| [Partition Coefficient] 2.79 | |
| [Usage] Medication. | |
| [Product Name] 2-[1-Methyl-5-(4-methylbenzoyl)-pyrrol-2-yl]acetic acid | |
| [Synonyms] 1H-Pyrrole-2-acetic acid, 1-methyl-5-(4-methylbenzoyl)- 1-Methyl-5-p-toluoylpyrrole-2-acetic acid 5-[(p-Tolyl)carbonyl]-1-methylpyrrole-2-acetic acid McN 2559 Tolectin Tolmetine | |
| [CAS] "CASEN_26171-23-3.htm">26171-23-3 | |
| [Formula] C15H15NO3 | |
| [Molecular Weight] 257.29000000000002 | |
| [EINECS] 247-497-2 | |
| [RTECS] UX9287000 | |
| [RTECS Class] Drug; Reproductive Effector | |
| [Merck] 12,9655 | |
| [Beilstein/Gmelin] 485305 | |
| [Beilstein Reference] 5-22-06-00392 | |
| [Small spills/leaks] Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces. | |
| [Stability] No data. | |
| [Incompatibilities] Strong oxidizing agents. |
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