| [Fire Fighting] Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire. | |
| [Ingestion] Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended. | |
| [Inhalation] If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention. | |
| [Skin] Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse. | |
| [Eyes] If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention. | |
| [Storage] Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage. | |
| [Handling] All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood. | |
| [Ingestion] Nausea, vomiting, and diarrhea may be seen. | |
| [Personal Protection] Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots. | |
| [Respirators] Use NIOSH/MSHA approved respirator appropriate for exposure of concern. | |
| [Exposure Effects] Symptoms are similar to hypercalcemia: anorexia, fatigue, headache, itching, and weakness. Polyneuropathy has been reported after acute intoxication. In humans, aortic stenosis was associated with high doses of vitamin D in pregnancy. However, conflicting results have been observed. In animal studies, toxic effects including fetotoxicity, spontaneous abortion and specific developmental abnormalities were observed. | |
| [Appearance] Colorless, crystalline solid. | |
| [Solubility in water] Insoluble | |
| [Melting Point] 95 - 99 | |
| [pKa/pKb] 13.98 (pKa) | |
| [Usage] Medication. | |
| [Product Name] 1alpha,25-Dihydroxycholecalciferol | |
| [Synonyms] 1,25-Dihydroxycholecalciferol 1,25-Dihydroxyvitamin D3 9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol, (1a,3b,5Z,7E)- Calcitriol Rocaltrol Topitriol | |
| [CAS] "CASEN_32222-06-3.htm">32222-06-3 | |
| [Formula] C27H44O3 | |
| [Molecular Weight] 416.64 | |
| [EINECS] 250-963-8 | |
| [RTECS] FZ4645000 | |
| [RTECS Class] Drug; Mutagen; Reproductive Effector | |
| [Merck] 12,1681 | |
| [Beilstein/Gmelin] 2065599 | |
| [Small spills/leaks] Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces. | |
| [Stability] No data. | |
| [Incompatibilities] Strong oxidizing agents. |
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