| [Fire Fighting] Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire. | |
| [Ingestion] Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended. | |
| [Inhalation] If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention. | |
| [Skin] Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse. | |
| [Eyes] If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention. | |
| [Storage] Cool dry location in a tightly sealed container. Avoid exposure to light. | |
| [Handling] Do not breath dust, get in eyes, on skin or on clothing. Avoid prolonged or repeated exposure. Always work in a chemical hood and while using the recommended protective equipment. | |
| [Inhalation] May be fatal if inhaled, ingested or absorbed through the skin. Causes irritation. | |
| [Skin] See inhalation. | |
| [Eyes] See inhalation | |
| [Ingestion] See inhalation. | |
| [Personal Protection] Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots. | |
| [Respirators] NIOSH/MSHA approved respirator. | |
| [Exposure Effects] Chronic exposure may cause congenitial malformations of the fetus. Studies havs shown mutagenic effects. Causes blood effects. | |
| [Poison Class] 1* | |
| [Appearance] Clusters of yellow needles. | |
| [Melting Point] 260-265 | |
| [pKa/pKb] 3.52 (pKa) | |
| [Partition Coefficient] .15 | |
| [Usage] Is a folic acid antagonist. | |
| [Product Name] N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid | |
| [Synonyms] 4-Aminofolic acid 4-Aminopteroylglutamic acid L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]- | |
| [CAS] "CASEN_54-62-6.htm">54-62-6 | |
| [Formula] C19H20N8O5 | |
| [Molecular Weight] 440.42 | |
| [EINECS] 200-209-9 | |
| [RTECS] MA1050000 | |
| [RTECS Class] Agricultural Chemical and Pesticide; Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data | |
| [Merck] 12,493 | |
| [Beilstein/Gmelin] 69045 | |
| [Beilstein Reference] 4-26-00-03831 | |
| [Small spills/leaks] Do not touch spilled material; stop leak if you can do so without risk. Use water spray to reduce vapors. Small spills: absorb with sand or other noncombustible absorbent material and place into containers for later disposal. Small dry spills: with clean shovel place material into clean, dry container and cover; move containers from spill area. Large spills: dike far ahead of spill for later disposal. | |
| [Stability] Stable at normal temperatures and pressures. | |
| [Incompatibilities] Strong oxidizing agents. | |
| [Decomposition] Oxides of carbon and nitrogen. |
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