| [Fire Fighting] Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire. | |
| [Ingestion] Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended. | |
| [Inhalation] If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention. | |
| [Skin] Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse. | |
| [Eyes] If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention. | |
| [Storage] Protect from light. Keep in a tightly closed container in a cool, dry location. | |
| [Handling] All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood. | |
| [Inhalation] Respiratory depression, pulmonary edema, and a loss of the gag reflex with possible aspiration may occur with phenothiazine overdose. | |
| [Skin] Itching, redness, swelling, irritation. | |
| [Eyes] Irritation. | |
| [Ingestion] Gastrointestinal abnormalities, especially constipation with possible obstruction, may occur with phenothiazine overdose. | |
| [Personal Protection] Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots. | |
| [Respirators] Not required for the normal use of this material. | |
| [Exposure Effects] Phenothiazines may interfere with the body's ability to thermoregulate, and cause elevated body temperature or reduced body temperature. Abnormally low blood pressure and elevated blood pressure have both been reported; abnormally low blood pressure is the more common serious effect. CNS depression, coma, agitation, extrapyramidal signs, and seizures may occur with overdose. Neuroleptic malignant syndrome has rarely occurred with therapeutic use and overdose. Most phenothiazines are rated pregnancy category C and should be used only when potential therapeutic benefit outweighs potential effects on the fetus. | |
| [Appearance] Clear, pale yellow, viscous liquid. | |
| [Solubility in water] Insoluble. | |
| [Melting Point] 220 | |
| [Boiling Point] 224 - 234 (0.5 torr) | |
| [Partition Coefficient] 4.88 | |
| [Usage] Antiemetic, antipsychotic. In the treatment of vertigo. | |
| [Product Name] 2-Chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine | |
| [Synonyms] 2-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)phenothiazine 2-Chloro-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazine 3-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)phenothiazine 3-Chloro-10-chlorperazine Capazine Chlormeprazine | |
| [CAS] "CASEN_58-38-8.htm">58-38-8 | |
| [Formula] C20H24ClN3S | |
| [Molecular Weight] 373.95 | |
| [EINECS] 200-379-4 | |
| [RTECS] SO2700000 | |
| [RTECS Class] Drug; Reproductive Effector; Human Data | |
| [Merck] 12,7942 | |
| [Beilstein/Gmelin] 48537 | |
| [Beilstein Reference] 4-27-00-01307 | |
| [Small spills/leaks] Use protective equipment. Absorb spill with inert material. Shove into a container for disposal. | |
| [Stability] Stable at normal temperatures and pressures. | |
| [Incompatibilities] Strong oxidizing agents. | |
| [Decomposition] No data. |
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