| [Fire Fighting] Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Runoff from fire control or dilution water may cause pollution. To extinguish fire, use carbon dioxide, dry chemical powder or appropriate foam. | |
| [Fire Potential] This material is probably combustible. | |
| [Ingestion] Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. | |
| [Inhalation] Get medical aid immediately. If breathing is difficult, give oxygen. Do not use mouth-to-mouth respiration if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. | |
| [Skin] Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. | |
| [Eyes] Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. | |
| [Storage] Deep freeze (below -20 C). Keep containers tightly closed. Store protected from moisture. Store protected from light. | |
| [Handling] Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Do not get in eyes, on skin, or on clothing. Keep container tightly closed. Do not ingest or inhale. Store protected from light. Use only in a chemical fume hood. Keep from contact with moist air and steam. | |
| [Inhalation] May cause effects similar to those described for ingestion. | |
| [Skin] Not available. Causes skin irritation, rashes, itching, dermatitis, photosensitivity, discoloration of the skin, acne, burning and hair loss. | |
| [Eyes] Causes eye irritation. | |
| [Ingestion] Harmful if swallowed. Ingestion may result in irritation of the esophagus, bleeding of the stomach and ulcer formation. May cause headaches, drowsiness, anorexia, blurred vision, eye discomfort, ringing in the ears, fatigue, dizziness, gingivitis, diarrhea, hair loss, cerebrospinal fluid effects, blood pressure depression, and cyanosis. May cause blood cell counts to decrease. People with preexisting liver or kidney malfunctions are at increased risk from this substance. Liver dysfunction is usually reversible, but may lead to cirrhosis. | |
| [Hazards] Contact with metals may evolve flammable hydrogen gas. | |
| [UN (DOT)] 2811 | |
| [Personal Protection] Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. | |
| [Respirators] A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use. | |
| [Exposure Effects] behavioral abnormalities, abnormal reflexes, and focal sensorimotor signs may occur following second or third dose of high-dose methotrexate. Acute or subacute neurologic toxicity may occur following intrathecal methotrexate. Parenteral or oral administration is unlikely to cause neurological damage. | |
| [Poison Class] 1* | |
| [Appearance] Odorless yellow to orange-brown crystalline powder. | |
| [Solubility in water] insoluble | |
| [Melting Point] 195 | |
| [pKa/pKb] 3.54 (pKa) | |
| [Partition Coefficient] -.28 | |
| [Usage] Antimetabolite. | |
| [Product Name] (+)-4-Amino-10-methylfolic acid | |
| [Synonyms] 2-[[4-[(2,4-Diaminopteridin-6-yl)methyl-methyl-amino]benzoyl]amino]pentanedioic acid 4-Amino-10-methylfolic acid 4-Amino-4-deoxy-N(10)-methylpteroylglutamate 4-Amino-4-deoxy-N(10)-methylpteroylglutamic acid Amethopterin Amethopterine | |
| [CAS] "CASEN_59-05-2.htm">59-05-2 | |
| [Formula] C20H22N8O5 | |
| [Molecular Weight] 454.45 | |
| [EINECS] 200-413-8 | |
| [RTECS] MA1225000 | |
| [RTECS Class] Agricultural Chemical and Pesticide; Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data; Primary Irritant | |
| [Merck] 12,6065 | |
| [Beilstein/Gmelin] 70669 | |
| [Beilstein Reference] 4-26-00-03833 | |
| [Small spills/leaks] Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Provide ventilation. | |
| [Stability] Stable at room temperature in closed containers under normal storage and handling conditions. Decomposes on exposure to light. | |
| [Incompatibilities] Strong oxidizing agents, strong acids, moisture, direct light. | |
| [Decomposition] Nitrogen oxides, carbon monoxide, carbon dioxide. | |
| [Combustion Products] Fire may produce irritating, corrosive and/or toxic gases. | |
| [UN Number] 2811 | |
| [Hazard Class] 6.1 | |
| [Packing Group] I; II; III |
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