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Dacarbazine

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[Fire Fighting]

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Non-combustible, substance itself does not burn but may decompose upon heating to produce irritating, corrosive and/or toxic fumes. Extinguishing media: Substance is noncombustible; use agent most appropriate to extinguish surrounding fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
[Fire Potential]

This material is probably combustible.
[Ingestion]

Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
[Inhalation]

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. DO NOT use mouth-to-mouth respiration.
[Skin]

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
[Eyes]

Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
[Storage]

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Refrigerator (approx 4 C).
[Handling]

Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation. Wash clothing before reuse.
[Inhalation]

Causes respiratory tract irritation. Can produce delayed pulmonary edema. Exposure to thermodegradation products may cause influenza-like symptoms such as chills, headache, mild respiratory discomfort, shaking of the limbs, and high fever.
[Skin]

Causes skin irritation. May cause erythema, and edema with crusting and scaling.
[Eyes]

Causes eye irritation. May cause chemical conjunctivitis.
[Ingestion]

May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause liver damage. Exposure may cause anemia and other blood abnormalities. May cause anemia, leukopenia, and thrombocytopenia.
[Personal Protection]

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
[Respirators]

A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
[Exposure Effects]

May cause cancer according to animal studies. Effects may be delayed. Chronic exposure may cause liver damage.
[Appearance]

White to ivory microcrystals or off-white crystalline solid.
[Melting Point]

250 - 255
[pKa/pKb]

9.58 (pKb)
[Usage]

Cytostatic drug.
[Product Name]

4-(Dimethyltriazeno)imidazole-5-carboxamide
[Synonyms]

(Dimethyltriazeno)imidazolecarboxamide
4-(3,3-Dimethyl-1-triazeno)imidazole-5-carboxamide
4-(5)-(3,3-Dimethyl-1-triazeno)imidazole-5(4)-carboxamide
4-(Dimethyltriazeno)imidazole-5-carboxamide
5-(3,3-Dimethyltriazeno)imidazole-4-carboxamide
DIR
[CAS]

"CASEN_4342-03-4.htm">4342-03-4
[Formula]

C6H10N6O
[Molecular Weight]

182.19
[EINECS]

224-396-1
[RTECS]

NI3950000
[RTECS Class]

Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data
[Merck]

12,2866
[Beilstein/Gmelin]

521487
[Small spills/leaks]

Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Provide ventilation.
[Stability]

Stable at room temperature in closed containers under normal storage and handling conditions.
[Incompatibilities]

Strong oxidizing agents.
[Decomposition]

Nitrogen oxides, carbon monoxide, carbon dioxide.