| [Fire Fighting] Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire use water spray, dry chemical, carbon dioxide, or appropriate foam. | |
| [Ingestion] Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. | |
| [Inhalation] Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. | |
| [Skin] Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. | |
| [Eyes] Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. | |
| [Storage] Store in a tightly closed container. Deep freeze (below -20 C). Store under an inert atmosphere. Store in a cool, dry area away from incompatible substances. | |
| [Handling] Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Do not get in eyes, on skin, or on clothing. Keep container tightly closed. Do not ingest or inhale. Store protected from light. Handle under an inert atmosphere. Use only in a chemical fume hood. | |
| [Inhalation] May cause respiratory tract irritation. | |
| [Skin] May cause skin irritation. | |
| [Eyes] May cause eye irritation. | |
| [Ingestion] May cause gastrointestinal irritation with nausea, vomiting and diarrhea. | |
| [Personal Protection] Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. | |
| [Respirators] A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use. | |
| [Exposure Effects] Chronic exposure may cause reproductive disorders and teratogenic effects. Prolonged exposure can cause systemic toxicity characterized by irrita bility, vomiting, loss of appetite, headache, dry skin, dermatitis, de creased immune response, diarrhea, and sweating. Avoid exposure durin g pregnancy, as the substance may cause malformation of the fetus. Ch ronic exposure may cause depression, corneal opacity, photosensitivity , abnormal liver function tests, and skeletal hyperostosis. | |
| [Appearance] Yellow-orange to orange crystalline powder; orange-brown chunky solid. | |
| [Solubility in water] Insoluble | |
| [Melting Point] 175 | |
| [Boiling Point] 412 | |
| [Density] 1.07 g/cm3 | |
| [pKa/pKb] 4.79 (pKa) | |
| [Partition Coefficient] 4.65 | |
| [Usage] Medication. | |
| [Product Name] 13-cis-Retinoic acid | |
| [Synonyms] (2Z,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)nona-2,4,6,8-tetraenoic acid 13-cis-Vitamin A acid Accutane Isotretinoin Neovitamin A acid Roaccutane | |
| [CAS] "CASEN_4759-48-2.htm">4759-48-2 | |
| [Formula] C20H28O2 | |
| [Molecular Weight] 300.48 | |
| [EINECS] 225-296-0 | |
| [RTECS] VH6440000 | |
| [RTECS Class] Drug; Mutagen; Reproductive Effector; Human Data | |
| [Beilstein/Gmelin] 1885770 | |
| [Beilstein Reference] 4-09-00-02388 | |
| [Small spills/leaks] Wash area with soap and water. Clean up spills immediately, using the appropriate protective equipment. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid generating dusty conditions. Provide ventilation. | |
| [Stability] Stable at normal temperatures in tightly closed containers under an inert atmosphere. Light sensitive. | |
| [Incompatibilities] Strong oxidizing agents. | |
| [Decomposition] Carbon monoxide, carbon dioxide, acrid smoke and fumes. |
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