| [Fire Fighting] Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire. | |
| [Ingestion] Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended. | |
| [Inhalation] If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention. | |
| [Skin] Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. | |
| [Eyes] If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention. | |
| [Storage] Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage. | |
| [Handling] All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood. | |
| [Skin] Rashes, pruritus, urticaria, and alopecia have been noted but are rare. | |
| [Personal Protection] Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots. | |
| [Respirators] Use NIOSH/MSHA approved respirator appropriate for exposure of concern. | |
| [Exposure Effects] Seizures and syncope have been seen in human overdose. Sedation and ataxia have not been seen in human overdose. With therapeutic use - seizures and tremor have rarely been reported in humans. Animal studies sedation and ataxia have occurred in animals receiving 80 to 500 mg/kg. Seizures and tremor occur in animals receiving 80 to 500 mg/kg. Terfenadine is not teratogenic in rats; teratogenicity was not noted in humans in a multicenter, prospective study. | |
| [Appearance] White to off-white crystalline powder. | |
| [Solubility in water] Slightly soluble | |
| [Melting Point] 146.5-148.5 | |
| [Usage] Medication. | |
| [Product Name] Terfenadine | |
| [Synonyms] 1-(4-tert-Butylphenyl)-4-(4-(alpha-Hydroxybenzhydryl)piperidino)butan-1-ol 1-(p-tert-Butylphenyl)-4-(4'-(alpha-hydroxydiphenylmethyl)-1'-piperidyl)-butanol Aldaban Allerplus | |
| [CAS] "CASEN_50679-08-8.htm">50679-08-8 | |
| [Formula] C32H41NO2 | |
| [Molecular Weight] 471.68 | |
| [EINECS] 256-710-8 | |
| [RTECS] TM4969000 | |
| [RTECS Class] Drug; Reproductive Effector; Human Data | |
| [Merck] 12,9307 | |
| [Beilstein/Gmelin] 5857899 | |
| [Small spills/leaks] Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces. | |
| [Stability] No data. | |
| [Incompatibilities] Strong oxidizing agents. |
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