| [Fire Fighting] Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire. | |
| [Ingestion] Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended. | |
| [Inhalation] If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention. | |
| [Skin] Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. | |
| [Eyes] If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention. | |
| [Storage] Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage. | |
| [Handling] All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood. | |
| [Inhalation] Interstitial pneumonitis occurs rarely and may be an allergic reaction during therapeutic use. | |
| [Skin] Pruritus, hyperpigmentation, flushing, alopecia, and jaundice may be noted. Herpetic lesions may occur. | |
| [Eyes] Nystagmus, diplopia, papilledema, photophobia and retinal hemorrhage may occur with therapeutic use. | |
| [Ingestion] Ausea, vomiting and diarrhea may occur. | |
| [Personal Protection] Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots. | |
| [Respirators] Respiratory protection should be an adjunct to and not a substitute for engineering controls.<BR>Organic vapor acid gas canister; done in the open, an area away from drafts and traffic | |
| [Exposure Effects] Procarbazine is a weak mao inhibitor. A hypertensive reaction may occur with concurrent use of sympathomimetic agents, tricyclic antidepressants, and foods with high tyramine content; these reactions are poorly documented. with therapeutic use - paresthesias, neuropathies, dizziness, headache, insomnia, frequent nightmares, nervousness, depression, hallucinations, seizures, coma and tremors have been reported. Procarbazine is not recommended for use during pregnancy or lactation. | |
| [pKa/pKb] 6.6 (pKa) | |
| [Partition Coefficient] .06 | |
| [Usage] Medication (vet). | |
| [Product Name] N-(1-Methylethyl)-4-((2-methylhydrazino)methyl)benzamide | |
| [Synonyms] 4-((2-Methylhydrazino)methyl)-n-Isopropylbenzamide Ibenzmethyzin n-(1-Methylethyl)-4 n-4-isopropylcarbamoylbenzyl-n'-methylhydrazine n-Isopropyl-alpha-(2-methylhydrazino)-p-toluamide p-(N'-Methylhydrazinomethyl)-n-Isopropylbenzamide | |
| [CAS] "CASEN_671-16-9.htm">671-16-9 | |
| [Formula] C12H19N3O | |
| [Molecular Weight] 221.3 | |
| [EINECS] 211-582-2 | |
| [RTECS] XS4550000 | |
| [RTECS Class] Tumorigen; Drug; Mutagen; Reproductive Effector | |
| [Merck] 12,7938 | |
| [Beilstein/Gmelin] 958270 | |
| [Small spills/leaks] Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces. | |
| [Stability] Stable in light, slowly oxidized in air. Hydrochloride stable @ room temperature (in presence of oxygen, oxidn is accelerated by incr temperature). | |
| [Incompatibilities] Strong oxidizing agents. |
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