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Acemetacin

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[Flash Point]

339
[Fire Fighting]

Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
[Fire Potential]

Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.
[Ingestion]

If swallowed, wash out mouth with water provided person is conscious. Call a physician.
[Inhalation]

If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.
[Skin]

In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
[Eyes]

In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.
[Inhalation]

TOXIC; inhalation, ingestion, or skin contact with material may cause severe injury or death. Effects of contact or inhalation may be delayed.
[Skin]

Contact with molten substance may cause severe burns to skin and eyes. See Inhalation.
[Eyes]

See Inhalation.
[Ingestion]

See Inhalation.
[Hazards]

Emits toxic fumes under fire conditions.
[EC Risk Phrase]

26/27/28
[EC Safety Phrase]

22 25 36/37/39 45
[UN (DOT)]

2811
[Personal Protection]

Wear appropriate government approved respirator, chemical-resistant gloves, safety goggles, other protective clothing.
[Respirators]

Wear positive pressure self-contained breathing apparatus (SCBA).
[Exposure Effects]

Very toxic by inhalation, in contact with skin and if swallowed.
[Solubility in water]

Slightly soluble
[Boiling Point]

637
[Vapor Pressure]

4E-17 (25 C)
[pKa/pKb]

2.60 (pKa)
[Heat Of Vaporization]

98.9 kJ/mol
[Usage]

An nsaid that specifically potentiates the cytoxicity of anthracyclines.
[Product Name]

Acemetacin
[Synonyms]

1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid carboxymethyl ester
1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid carboxymethyl ester
2-[2-[1-[(4-Chlorophenyl)carbonyl]-5-methoxy-2-methylindol-3-yl]acetyloxy]acetic acid
[CAS]

"CASEN_53164-05-9.htm">53164-05-9
[Formula]

C21H18ClNO6
[Molecular Weight]

415.83
[EINECS]

258-403-4
[RTECS]

NL3521400
[RTECS Class]

Drug; Reproductive Effector
[Merck]

12,27
[Beilstein/Gmelin]

501672
[Beilstein Reference]

5-22-05-00241
[Small spills/leaks]

Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
[Stability]

Stable at normal temperatures and pressures.
[Decomposition]

Carbon monoxide, Carbon dioxide, Nitrogen oxides.
[Combustion Products]

Fire may produce irritating, corrosive and/or toxic gases.
[UN Number]

2811
[Hazard Class]

6.1
[Packing Group]

II