| [Fire Fighting] Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire. | |
| [Ingestion] Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended. | |
| [Inhalation] If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention. | |
| [Skin] Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse. | |
| [Eyes] If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention. | |
| [Storage] Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage. | |
| [Handling] All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood. | |
| [Skin] Dermatitis, photosensitivity, and dermatomyositis may occur following therapy with hmg-coa reductase inhibitors. | |
| [Ingestion] Diarrhea and flatulence were commonly reported adverse effects during clinical trials. Pancreatitis was associated with gemfibrozil-lovastatin combined therapy. | |
| [Personal Protection] Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots. | |
| [Respirators] Use NIOSH/MSHA approved respirator appropriate for exposure of concern. | |
| [Exposure Effects] peripheral neuropathies have been reported following therapy with the hmg-coa enzyme inhibitors. Therapeutic administration of hmg-coa enzyme inhibitors may cause insomnia, behavioral changes, and extrapyramidal symptoms. Congenital abnormalities were reported in an infant whose mother ingested dextroamphetamine and lovastatin during the first trimester. <br>Skeletal abnormalities of the ribs and vertebra have been reported in female rats administered lovastatin 800 mg/kg/day during gestation. <br>Animal studies indicate HMG-CoA enzyme inhibitors are excreted into breast milk. | |
| [Appearance] White crystals. | |
| [Solubility in water] insoluble | |
| [Melting Point] 174.5 (under nitrogen) | |
| [Usage] Medication. | |
| [Product Name] 1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl 2-methylbutanoate | |
| [Synonyms] [(1S,3R,7R,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxo-oxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate 1,2,6,7,8,8a-Hexahydro-beta,delta-dihydroxy-2,6-dimethyl-8-(2-methyl-1-oxobutyoxy)-1-naphthaleneheptanoic acid delta-lactone 2beta, 6alpha-Dimethyl-8alpha-(2-methyl-1-oxobutoxy)-mevinic acid lactone Mevinacor Paschol Rovacor | |
| [CAS] "CASEN_75330-75-5.htm">75330-75-5 | |
| [Formula] C24H36O5 | |
| [Molecular Weight] 404.55 | |
| [RTECS] EK7907000 | |
| [RTECS Class] Drug; Reproductive Effector; Human Data | |
| [Merck] 12,5616 | |
| [Beilstein/Gmelin] 3631989 | |
| [Small spills/leaks] Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces. | |
| [Stability] No data. | |
| [Incompatibilities] Strong oxidizing agents. |
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