Efonidipine hydrochloride ethanolate (111011-76-8)

Identification
Name:	Efonidipine hydrochloride ethanolate
Synonyms:	Ethanol, compd. with 2-(phenyl(phenylmethyl)amino)ethyl 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3-pyridinecarboxylate monohydrochloride;NZ 105 ethanolate;Efonidipine hydrochloride (JAN);Landel;3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-(5,5-dimethyl-1,3,2-dioxaphosphorinan-2-yl)-4-(3-nitrophenyl)-, 2-(phenyl(phenylmethyl)amino)ethyl ester, P-oxide, monohydrochloride;Efonidipine.HCl ethanolate;2-(benzyl-phenyl-amino)ethyl 5-(5,5-dimethyl-2-oxo-1,3-dioxa-2$l^C36H45ClN3O8P-phosphacyclohex-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate; ethanol; hydrochloride;Efonidipine hydrochloride;Efonidipine hydrochloride ethanol;3-Pyridinecarboxylic acid, 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-(phenyl(phenylmethyl)amino)ethyl ester, monohydrochloride, compd. with ethanol (1;1);Landel (TN);
CAS:	111011-76-8
Molecular Formula:	C₃₆H₄₅ClN₃O₈P
Molecular Weight:	631.66
InChI:	InChI=1/C34H38N3O7P.C2H6O.ClH/c1-24-30(33(38)42-19-18-36(28-15-9-6-10-16-28)21-26-12-7-5-8-13-26)31(27-14-11-17-29(20-27)37(39)40)32(25(2)35-24)45(41)43-22-34(3,4)23-44-45;1-2-3;/h5-17,20,31,35H,18-19,21-23H2,1-4H3;3H,2H2,1H3;1H
Molecular Structure:
Properties
Flash Point:	405.5°C
Boiling Point:	746.9°Cat760mmHg
Density:	1.3g/cm³
Biological Activity:	Selective blocker of L-type and T-type Ca 2+ channels. Displays minimal inhibition of N- and P/Q-type channels and no inhibition of R-type channels. R (-) and S (+)-enantiomers displays different channel selectivity; S (+)-Efonidipine blocks L-type and T-type channels whereas R (-)-Efonidipine displays selectivity for T-type channels. Exhibits antihypertensive activity.
Flash Point:	405.5°C
Safety Data

Efonidipine hydrochloride ethanolate (111011-76-8)

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