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4-Octadecene-1,3-diol,2-amino-, (2S,3R,4E)- (123-78-4)

Identification
Name:4-Octadecene-1,3-diol,2-amino-, (2S,3R,4E)-
Synonyms:4-Octadecene-1,3-diol,2-amino-, (E)-D-erythro- (8CI);4-Octadecene-1,3-diol, 2-amino-,[R-[R*,S*-(E)]]-;(-)-D-erythro-Sphingosine;(-)-Sphingosine;(2S,3R)-Sphingosine;(2S,3R,4E)-2-Amino-4-octadecene-1,3-diol;(4E)-Sphingenine;4-Sphingenine;4-trans-Sphingenine;D-(+)-erythro-4-trans-Sphingenine;D-Sphingosine;D-erythro-C18-Sphingosine;D-erythro-Sphingosine;Erythrosphingosine;Sphingosine;erythro-4-Sphingenine;erythro-C18-Sphingosine;trans-4-Sphingenine;
CAS:123-78-4
EINECS: 204-651-3
Molecular Formula: C18H37NO2
Molecular Weight: 299.50 .
InChI: InChI=1/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/b15-14+
Molecular Structure: (C18H37NO2) 4-Octadecene-1,3-diol,2-amino-, (E)-D-erythro- (8CI);4-Octadecene-1,3-diol, 2-amino-,[R-[R*,S*-(E)]]...
Properties
Transport:OTH
Melting Point: 81-82 °C
Flash Point: 445.9°Cat760mmHg
Boiling Point: 445.9°Cat760mmHg
Density:0.939g/cm3
Stability:Stable. Incompatible with strong acids, strong bases, strong oxidizing agents.
Refractive index:1.489
Appearance:White to off-white crystalline powder
Specification:

1.  Sphingosine (CAS NO.123-78-4), its Synonyms are 2-Aminooctadec-4-ene-1,3-diol ; 4-Octadecene-1,3-diol, 2-amino-, (R-(R*,S*-(E)))- ; (E)-2-Amino-4-octadecan-1,3-diol . It is white crystalline solid.
2. Sphingosine is an 18-carbon amino alcohol with an unsaturated hydrocarbon chain, which forms a primary part of sphingolipids, a class of cell membrane lipids that include sphingomyelin, an important phospholipid.

Biological Activity: Inhibitor of protein kinase C and calmodulin-dependent enzymes, but may stimulate mast cells by activation of protein kinase C.
Flash Point: 445.9°Cat760mmHg
Storage Temperature: −20°C
Usage:

1.Sphingosine (CAS NO.123-78-4) does not inhibit protein kinase A or myosin light chain kinase;  it inhibits calmodulin-dependent enzymes; it is natural isomer of sphingosine .
2. Sphingosine can be phosphorylated in vivo via two kinases, sphingosine kinase type 1 and sphingosine kinase type 2. This leads to the formation of sphingosine-1-phosphate, a potent signaling lipid.

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