1H-Pyrazolo[3,4-d]pyrimidin-4-amine,3-(4-chlorophenyl)-1-(1,1-dimethylethyl)- (172889-27-9)

Identification
Name:	1H-Pyrazolo[3,4-d]pyrimidin-4-amine,3-(4-chlorophenyl)-1-(1,1-dimethylethyl)-
Synonyms:	AGL 1879;PP 2 (enzyme inhibitor);1-tert-butyl-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine;1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-(4-chlorophenyl)-1-(1,1-dimethylethyl)-;1-tert-butyl-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine;
CAS:	172889-27-9
Molecular Formula:	C₁₅H₁₆ClN₅
Molecular Weight:	301.77404
InChI:	InChI=1S/C15H16ClN5/c1-15(2,3)21-14-11(13(17)18-8-19-14)12(20-21)9-4-6-10(16)7-5-9/h4-8H,1-3H3,(H2,17,18,19)
Molecular Structure:
Properties
Melting Point:	214-216ºC
Density:	1.35 g/cm³
Refractive index:	1.676
Water Solubility:	Soluble to 25 mM in DMSO or to 10 mM in ethanol.
Solubility:	Soluble to 25 mM in DMSO or to 10 mM in ethanol.
Appearance:	White solid
Biological Activity:	Selective inhibitor of Src-family tyrosine kinases. Inhibits p56 lck and p59 fynT (IC 50 values are 4 and 5 nM respectively). Displays > 10000-fold selectivity over ZAP-70 and JAK2. Moderately inhibits CSK (IC 50 = 0.73 μ M).
Safety Data