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1H-Benzotriazole,4,5,6,7-tetrabromo- (17374-26-4)

Identification
Name:1H-Benzotriazole,4,5,6,7-tetrabromo-
Synonyms:Benzotriazole,4,5,6,7-tetrabromo- (6CI,7CI);4,5,6,7-Tetrabromo-1H-benzotriazole;4,5,6,7-Tetrabromobenzotriazole;NSC 231634;TBB (enzyme inhibitor);
CAS:17374-26-4
Molecular Formula: C6HBr4N3
Molecular Weight: 434.70824
InChI: InChI=1S/C6HBr4N3/c7-1-2(8)4(10)6-5(3(1)9)11-13-12-6/h(H,11,12,13)
Molecular Structure: (C6HBr4N3) Benzotriazole,4,5,6,7-tetrabromo- (6CI,7CI);4,5,6,7-Tetrabromo-1H-benzotriazole;4,5,6,7-Tetrabromobe...
Properties
Density:2.84 g/cm3
Refractive index:1.8
Water Solubility:Soluble to 100 mM in DMSO and to 15 mM in Ethanol
Solubility:Soluble to 100 mM in DMSO and to 15 mM in Ethanol
Appearance:Off-white solid
Biological Activity: A cell-permeable, selective inhibitor of casein kinase-2 (CK2) (IC 50 = 0.9 and 1.6 μ M for rat liver and human recombinant CK2 respectively). Exhibits modest discrimination between CK2 subunits, with K i values ranging from 80 nM to 210 nM. Acts in an ATP/GTP-competitive manner and displays one to two orders of magnitude selectivity over a panel of 33 protein kinases.
Storage Temperature: 2-8°C
Color: white
Usage:TBB is one of the most selective protein kinase inhibitors known, and when tested against a panel of 33 serine/threonine and tyrosine protein kinases, only three exhibited moderate inhibition by TBB, with Ki values one to two orders of magnitude hig
Safety Data