Identification |
Name: | 1H-Benzotriazole,4,5,6,7-tetrabromo- |
Synonyms: | Benzotriazole,4,5,6,7-tetrabromo- (6CI,7CI);4,5,6,7-Tetrabromo-1H-benzotriazole;4,5,6,7-Tetrabromobenzotriazole;NSC 231634;TBB (enzyme inhibitor); |
CAS: | 17374-26-4 |
Molecular Formula: | C6HBr4N3 |
Molecular Weight: | 434.70824 |
InChI: | InChI=1S/C6HBr4N3/c7-1-2(8)4(10)6-5(3(1)9)11-13-12-6/h(H,11,12,13) |
Molecular Structure: |
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Properties |
Density: | 2.84 g/cm3 |
Refractive index: | 1.8 |
Water Solubility: | Soluble to 100 mM in DMSO and to 15 mM in Ethanol |
Solubility: | Soluble to 100 mM in DMSO and to 15 mM in Ethanol |
Appearance: | Off-white solid |
Biological Activity: | A cell-permeable, selective inhibitor of casein kinase-2 (CK2) (IC 50 = 0.9 and 1.6 μ M for rat liver and human recombinant CK2 respectively). Exhibits modest discrimination between CK2 subunits, with K i values ranging from 80 nM to 210 nM. Acts in an ATP/GTP-competitive manner and displays one to two orders of magnitude selectivity over a panel of 33 protein kinases. |
Storage Temperature: | 2-8°C |
Color: | white |
Usage: | TBB is one of the most selective protein kinase inhibitors known, and when tested against a panel of 33 serine/threonine and tyrosine protein kinases, only three exhibited moderate inhibition by TBB, with Ki values one to two orders of magnitude hig |
Safety Data |
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