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L-Alaninamide,1-[[(2-nitrophenyl)amino]carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)- (180046-99-5)

Identification
Name:L-Alaninamide,1-[[(2-nitrophenyl)amino]carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-
Synonyms:SDZ NKT 343
CAS:180046-99-5
Molecular Formula: C33H33 N5 O5
Molecular Weight: 579.64562
InChI: InChI=1/C33H33N5O5/c1-36(22-23-10-3-2-4-11-23)32(40)28(21-24-17-18-25-12-5-6-13-26(25)20-24)34-31(39)30-16-9-19-37(30)33(41)35-27-14-7-8-15-29(27)38(42)43/h2-8,10-15,17-18,20,28,30H,9,16,19,21-22H2,1H3,(H,34,39)(H,35,41)/t28-,30-/m0/s1
Molecular Structure: (C33H33N5O5) SDZ NKT 343
Properties
Flash Point: 493.8°C
Boiling Point: 892.8°Cat760mmHg
Density:1.327g/cm3
Refractive index:1.676
Biological Activity: Highly selective human tachykinin NK 1 receptor antagonist (IC 50 values are 0.62 and 451 nM for human and rat receptors respectively) that displays > 130-fold selectivity over human NK 2 and NK 3 receptors. Potently antagonizes SP-induced Ca 2+ efflux in vitro and inhibits mechanical hyperalgesia in vivo .
Flash Point: 493.8°C
Safety Data
 

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