| Identification | |
| Name: | Mycophenolic acid |
| Synonyms: | 4-Hexenoic acid,6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-, (E)- (8CI);(E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoicacid;Melbex; |
| CAS: | 24280-93-1 |
| EINECS: | 246-119-3 |
| Molecular Formula: | C17H20O6 |
| Molecular Weight: | 320.3371 |
| InChI: | InChI=1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)/b9-4+ |
| Molecular Structure: |  |
| Properties | |
| Transport: | 2811 |
| Melting Point: | 141oC |
| Density: | 1.29 g/cm3 |
| Stability: | Stable at normal temperatures and pressures. |
| Water Solubility: | Almost insoluble in cold water. Soluble in alcohol |
| Solubility: | Almost insoluble in cold water. Soluble in alcohol |
| Appearance: | White to off-white powder |
| Specification: |
? Mycophenolic acid , with CAS number of 24280-93-1, can be called 6-(1,3-Dihydro-7-hydroxy-5-methoxy-4-methyl-1-oxoisobenzofuran-6-yl)-4-methyl-4-hexanoic acid ; 6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid .?It is a?white to off-white powder. Mycophenolic acid (CAS NO.24280-93-1) is an antibiotic produced by Penicillium brevi-compactum, P. Stoloniferum and related spp. A selective inhibitor of lymphocyte proliferation by blocking inosine monophosphate dehydrogenase, an enzyme involved in the de novo synthesis of purine nucleot. |
| Report: |
EPA Genetic Toxicology Program. |
| Packinggroup: | III |
| Biological Activity: | Immunosuppressive agent with antiviral and antitumor effects in vitro and in vivo . Potently inhibits inosine monophosphate dehydrogenase, thus inhibiting de novo GTP synthesis leading to decreased RNA and DNA synthesis. Reversibly inhibits proliferation of T and B lymphocytes and antibody formation. |
| Usage: | An antibiotic produced by Penicillium brevi-compactum, P. Stoloniferum and related spp. A selective inhibitor of lymphocyte proliferation by blocking inosine monophosphate dehydrogenase, an enzyme involved in the de novo synthesis of purine nucleot |
| Safety Data | |
| Hazard Symbols |
Xn:Harmful
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