| Identification | |
| Name: | Doxorubicin hydrochloride |
| Synonyms: | 5,12-Naphthacenedione,10-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-,hydrochloride, (8S,10S)- (9CI);5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-,hydrochloride, (8S-cis)-;Adriamycin, hydrochloride (8CI);ADM hydrochloride;ADR;Adriablastina CS;Adriacin;Adriamycin;Adriblastin;Adriblastina;Adriblastina RD;DOX HCl;FI 106;FI 6804;Lipo-Dox; |
| CAS: | 25316-40-9 |
| EINECS: | 246-818-3 |
| Molecular Formula: | C27H30ClNO11 |
| Molecular Weight: | 579.99 |
| InChI: | InChI=1/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10?,13?,15-,17?,22?,27-;/m0./s1 |
| Molecular Structure: | ![(C27H30ClNO11) 5,12-Naphthacenedione,10-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,...](https://img.guidechem.com/casimg/25316-40-9.gif) |
| Properties | |
| Stability: | Stable at room temperature in closed containers under normal storage and handling conditions. |
| Solubility: | 2% sol in water; soluble in aqueous alcohols; moderately soluble in anhydrous methanol; insoluble in non-polar organic solvents In water, 2,600 mg/L at 25 deg C (est) |
| Appearance: | Orange-Red Crystalline Solid |
| Specification: |
? Doxorubicin hydrochloride , with CAS number of 25316-40-9, can be called (8S,10S)-10-((3-Amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-8-glycoloyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione hydrochloride ; Adriacin ; Adriamycin PFS ; Doxorubicin HCl . It is an?orange-red crystalline solid,?used as an antineoplastic,?Doxorubicin hydrochloride (CAS NO.25316-40-9) are weak chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. |
| Report: |
NTP 10th Report on Carcinogens. EPA Genetic Toxicology Program. |
| Biological Activity: | Antitumor antibiotic agent that inhibits DNA topoisomerase II. DNA intercalator that inhibits nucleic acid synthesis and induces apoptosis. |
| Color: | Red, crystalline solid |
| Usage: | Used as an antineoplastic |
| Safety Data | |
| Hazard Symbols |
T: Toxic
T+: Very toxic
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