| Identification | |
| Name: | EO 1428 |
| Synonyms: | EO 1428 |
| CAS: | 321351-00-2 |
| Molecular Formula: | C20H16BrClN2O |
| Molecular Weight: | 415.716 |
| InChI: | InChI=1/C20H16BrClN2O/c1-12-4-2-3-5-15(12)20(25)16-8-7-14(11-17(16)22)24-19-9-6-13(21)10-18(19)23/h2-11,24H,23H2,1H3 |
| Molecular Structure: |  |
| Properties | |
| Flash Point: | 265.828°C |
| Boiling Point: | 515.935°C at 760 mmHg |
| Density: | 1.483g/cm3 |
| Refractive index: | 1.689 |
| Biological Activity: | Selective inhibitor of p38 α and p38 β 2 that displays no activity at p38 γ , p38 δ , ERK1/2 and JNK1. Inhibits production of inflammatory cytokines including IL-8, TNF- α , IL-6, IL-1 β and IL-10 (IC 50 values are 4, 5, 17, 30 and 74 nM respectively). Displays anti-inflammatory activity in murine models of acute and chronic dermatitis. |
| Flash Point: | 265.828°C |
| Safety Data | |
 |
|
