| Identification | |
| Name: | 2-methyl-1,2-di-3-pyridyl-1-propanone |
| Synonyms: | 2-Methyl-1,2-di(3-pyridyl)-1-propanone; metyrapone; 1-methyl-1-(3-pyridyl)ethyl 3-pyridyl ketone |
| CAS: | 54-36-4 |
| EINECS: | 200-206-2 |
| Molecular Formula: | C14H14N2O |
| Molecular Weight: | 226.2774 |
| InChI: | InChI=1/C14H14N2O/c1-14(2,12-6-4-8-16-10-12)13(17)11-5-3-7-15-9-11/h3-10H,1-2H3 |
| Molecular Structure: |  |
| Properties | |
| Flash Point: | 189.3°C |
| Boiling Point: | 384.4°Cat760mmHg |
| Density: | 1.12g/cm3 |
| Refractive index: | 1.564 |
| Solubility: | SOL IN METHANOL & CHLOROFORM |
| Specification: |
Metyrapone ,its CAS NO. is 54-36-4,the synonyms is 1,2-Di-3-pyridyl-2-methyl-1-propanone ; 1-Propanone, 1,2-di-3-pyridyl-2-methyl- ; 1-Propanone, 2-methyl-1,2-di-3-pyridinyl- ; 2-Methyl-1,2-bis(3-pyridyl)-1-propanone ; 2-Methyl-1,2-di-3-pyridyl-1-propanone ; EINECS 200-206-2 ; HSDB 2500 ; Methapyrapone ; Metyraponum ; NSC 25265 ; UNII-ZS9KD92H6V . |
| Biological Activity: | Cytochrome P450 inhibitor. Blocks glucocorticoid synthesis via inhibition of steroid 11- β hydroxylase (CYP11B1) activity (IC 50 = 7.83 μ M). Also inhibits CYP3A4 and cytochrome P450-mediated ω / ω -1 hydroxylase activity. |
| Flash Point: | 189.3°C |
| Color: | CRYSTALS FROM ETHER & PENTANE WHITE TO LIGHT AMBER, FINE CRYSTALLINE POWDER |
| Safety Data | |
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