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Pyrrolo[2,3-b]indol-5-ol,1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, 5-(N-methylcarbamate), (3aS,8aR)- (57-47-6)

Identification
Name:Pyrrolo[2,3-b]indol-5-ol,1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, 5-(N-methylcarbamate), (3aS,8aR)-
Synonyms:Physostigmine(8CI); Pyrrolo[2,3-b]indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-,methylcarbamate (ester), (3aS,8aR)- (9CI); Pyrrolo[2,3-b]indol-5-ol,1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, methylcarbamate (ester), (3aS-cis)-;(-)-Eserine; (-)-Physostigmine; Cogmine; Eserine; Esromiotin; MCV 4484; NIH10421; NSC 30782; Physostol
CAS:57-47-6
EINECS: 200-332-8
Molecular Formula: C15H21 N3 O2
Molecular Weight: 275.3463
InChI: InChI=1S/C15H21N3O2/c1-15-7-8-17(3)13(15)18(4)12-6-5-10(9-11(12)15)20-14(19)16-2/h5-6,9,13H,7-8H2,1-4H3,(H,16,19)
Molecular Structure: (C15H21N3O2) Physostigmine(8CI); Pyrrolo[2,3-b]indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-,methylcarbam...
Properties
Transport:UN 1544 6.1/PG 1
Flash Point: 191.8°C
Boiling Point: 393.5°Cat760mmHg
Density:1.166g/cm3
Refractive index:1.567
Solubility:SLIGHTLY SOL IN WATER; SOL IN ALC, BENZENE, CHLOROFORM, OILS
VERY SOL IN DICHLOROMETHANE
Sol in ether
Sol in dilute acids
Specification:

1.General Description :White, odorless, microcrystalline powder. Used as a cholinergic (anticholinesterase) agent and as a veterinary medication.
2.Health Hazard :Super toxic. Probable oral lethal dose is less than 5 mg/kg for a 70 kg (150 lb.) person. Material is a cholinesterase inhibitor. Effects of exposure may involve the respiratory, gastrointestinal, cardiovascular and central nervous systems. Death occurs due to respiratory paralysis or impaired cardiac function. Time to death may vary from 5 minutes to 24 hours, in severely poisoned patients, depending on factors such as the dose and route. Persons with asthma and/or persons that require drugs containing choline esters are at risk.
3.Fire Hazard : Physostigmine (CAS NO.57-47-6) is a slight fire hazard. When heated to decomposition Physostigmine emits toxic fumes of nitrogen oxides. Keep from light and heat.

Report:

EPA Extremely Hazardous Substances List. Reported in EPA TSCA Inventory.

Packinggroup: II
Flash Point: 191.8°C
Storage Temperature: 2-8°C
Color: ORTHORHOMBIC SPHENOIDAL PRISMS OR CLUSTERS OF LEAFLETS FROM ETHER OR BENZENE
WHITE MICROCRYSTALLINE POWDER
Colorless or pinkish crystals
Usage:Physostigmine base (Eserine-Base) is used as bulk pharmaceuticals (parasympathomimetic, cholinergic, ophthalmic, anti-Alzheimer). Product Data Sheet
Safety Data
Hazard Symbols
 

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