| Identification | |
| Name: | Geldanamycin,17-demethoxy-17-(2-propenylamino)- |
| Synonyms: | 2-Azabicyclo[16.3.1]docosane,geldanamycin deriv.; 17-(Allylamino)-17-demethoxygeldanamycin;17-(Allylamino)-17-desmethylgeldanamycin; 17-(Allylamino)geldanamycin;17-Demethoxy-17-allylaminogeldanamycin; 17AAG; BMS 722782; CP 127374; KOS 953;NSC 330507; Tanespimycin |
| CAS: | 75747-14-7 |
| Molecular Formula: | C31H43 N3 O8 |
| Molecular Weight: | 585.69 |
| InChI: | InChI=1/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-11,15-17,19,24-25,27,29,33,36H,1,12-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9+,18-10-,20-15+/t17-,19+,24+,25+,27-,29+/m1/s1 |
| Molecular Structure: | ![(C31H43N3O8) 2-Azabicyclo[16.3.1]docosane,geldanamycin deriv.; 17-(Allylamino)-17-demethoxygeldanamycin;17-(Allyl...](https://img1.guidechem.com/chem/e/dict/123/75747-14-7.jpg) |
| Properties | |
| Flash Point: | 436.3°C |
| Boiling Point: | 797.8°C at 760 mmHg |
| Density: | 1.21 |
| Refractive index: | 1.566 |
| Solubility: | DMSO: soluble |
| Appearance: | Dark purple solid |
| Specification: |
The extinguishing agent of 17-Aag (CAS NO. 75747-14-7) are dry powder, foam, sand, carbon dioxide, water mist. |
| Biological Activity: | Inhibitor of heat shock protein 90 (Hsp90) chaperone activity, and an analog of geldanamycin (9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9-carbamate ). Subsequently inhibits the activity of oncogenic proteins such as p185 erbB-2 (IC 50 = 31 nM), N-ras, Ki-ras and c-Akt. Antitumor in vivo . |
| Flash Point: | 436.3°C |
| Storage Temperature: | −20°C |
| Usage: |
It is a substance that is being studied in the treatment of cancer, specific young patients with certain types of leukemia or solid tumors, especially kidney tumors. |
| Safety Data | |
 |
|
