| Identification | |
| Name: | Geldanamycin,17-demethoxy-15-methoxy-11-O-methyl-, (15R)- |
| Synonyms: | Antibiotic TAN 420F;Herbimycin A;NSC 305978; |
| CAS: | 70563-58-5 |
| Molecular Formula: | C30H42N2O9 |
| Molecular Weight: | 574.66248 |
| InChI: | InChI=1S/C30H42N2O9/c1-16-10-9-11-23(37-5)28(41-30(31)36)18(3)12-17(2)27(40-8)24(38-6)13-19(4)26(39-7)21-14-20(33)15-22(25(21)34)32-29(16)35/h9-12,14-15,17,19,23-24,26-28H,13H2,1-8H3,(H2,31,36)(H,32,35)/b11-9+,16-10+,18-12+/t17-,19-,23-,24-,26+,27+,28-/m0/s1 |
| Molecular Structure: |  |
| Properties | |
| Density: | 1.19 g/cm3 |
| Refractive index: | 1.545 |
| Water Solubility: | DMSO: 7.5 mg/mL DMSO stock solution can be diluted in osate buffered saline. The ratio of buffer:DMSO should be greater than 500:1 |
| Solubility: | DMSO: 7.5 mg/mL DMSO stock solution can be diluted in osate buffered saline. The ratio of buffer:DMSO should be greater than 500:1 |
| Appearance: | yellow powder |
| Specification: | Safety Statements:22-24/25-36-26 22:Do not breathe dust 24/25:Avoid contact with skin and eyes 36:Wear suitable protective clothing 26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice |
| HS Code: | 29419000 |
| Biological Activity: | Ansamycin antibiotic that acts as a Src family kinase inhibitor. Binds to the SH domain and inhibits the activity of p60 v-src and p210 BCR-ABL . Exhibits antiangiogenic activity in endothelial cells in vitro . Also inhibits Hsp90 and impairs recovery from heat shock. |
| Storage Temperature: | −20°C |
| Color: | yellow |
| Safety Data | |
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