Home >> msds >> (2S,5R,6R)-6-[(R)-2-Amino-2-phenylacetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

(2S,5R,6R)-6-[(R)-2-Amino-2-phenylacetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

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[Flash Point]

110
[Autoignition]

285
[Fire Fighting]

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.
[Fire Fighting]

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.
[Fire Potential]

Combustible material: may burn but does not ignite readily.
[Ingestion]

Get medical aid. Wash mouth out with water.
[Ingestion]

Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
[Inhalation]

If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
[Inhalation]

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
[Inhalation]

Causes respiratory tract irritation.
[Skin]

Causes skin irritation.
[Skin]

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
[Skin]

Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.
[Eyes]

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
[Eyes]

If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.
[Eyes]

Causes eye irritation.
[Storage]

Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
[Storage]

Store in a cool, dry place. Store in a tightly closed container.
[Handling]

All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
[Handling]

Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Use only in a chemical fume hood.
[Ingestion]

May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
[Skin]

Contact dermatitis may occur due to hypersensitivity reactions.
[Ingestion]

Diarrhea, nausea, vomiting, and abdominal pain may occur.
[Hazards]

When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.
[EC Risk Phrase]

R 34
[EC Safety Phrase]

S 26 36/37/39 45
[UN (DOT)]

3265
[Personal Protection]

Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
[Personal Protection]

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
[Respirators]

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
[Respirators]

Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
[Exposure Effects]

drowsiness, myoclonus, seizures, and coma may occur following large iv doses. Neurological side effects may be more common in patients with impaired renal function.
[Appearance]

White solid.
[Appearance]

White, crystalline powder. Odorless or has a faint odor characteristic of the penicillins.
[Solubility in water]

1 gm dissolves in about 90 ml
[Solubility in water]

575 g/L (20 C)
[Melting Point]

35 - 38
[Melting Point]

202
[Boiling Point]

258
[Vapor Pressure]

0.014 (25 C)
[pKa/pKb]

3.03 (pKb)
[pKa/pKb]

2.61 (pKa)
[Heat Of Vaporization]

49.6 kJ/mol
[Usage]

Antibiotic.
[Product Name]

(2S,5R,6R)-6-[(R)-2-Amino-2-phenylacetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
[Synonyms]

(2S,5R,6R)-6-((R)-2-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
1,9-Nonanediamine
Alpen
Amfipen
Aminobenzylpenicillin
D(-)-alpha-Aminobenzylpenicillin
D-(-)-alpha-Aminopenicillin
Nonane-1,9-diamine
[CAS]

"CASEN_646-24-2.htm">646-24-2
[CAS]

"CASEN_69-53-4.htm">69-53-4
[Formula]

C16H19N3O4S
[Formula]

C9H22N2
[Molecular Weight]

158.29
[Molecular Weight]

349.41
[EINECS]

200-709-7
[EINECS]

211-470-3
[RTECS]

XH8350000
[RTECS Class]

Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data
[Merck]

12,628
[Beilstein/Gmelin]

1737533
[Beilstein/Gmelin]

629178
[Beilstein Reference]

4-04-00-01364
[EC Class]

irritant
[Small spills/leaks]

Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
[Small spills/leaks]

Vacuum or sweep up material and place into a suitable disposal container.
[Disposal Code]

3
[Incompatibilities]

Acids, acid chlorides, acid anhydrides, oxidizing agents.
[Stability]

No data.
[Stability]

Stable under normal temperatures and pressures. Absorbs carbon dioxide from the air.
[Incompatibilities]

Strong oxidizing agents.
[Decomposition]

Nitrogen oxides, carbon monoxide, carbon dioxide.
[Combustion Products]

Fire may produce irritating, corrosive and/or toxic gases.
[UN Number]

3265
[Hazard Class]

8
[Packing Group]

I; II; III
[HS Code]

2921 29 00