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Ergonovine maleate (129-51-1)

Identification
Name:Ergonovine maleate
Synonyms:Metriclavin;Ergonovine, maleate (1:1);Ergotrate Maleate;Ergomet;Cornocentin;Ergometrine maleate (JP14);Ergotrate;Ergometrine (TN);D-Ergonovine maleate;Ergonovine maleate (USP);Ermetrin;Ergonovine maleate (TN);Ergoline-8-.beta.-carboxamide, 9, 10-didehydro-N- ((S)-2-hydroxy-1-methylethyl)-6-methyl-, maleate (1:1) (salt);Ergometrine acid maleate;Ergotrate maleate (TN);Ergometrin maleate;Ergoline-8.beta.-carboxamide, 9,10-didehydro-N- ((S)-2-hydroxy-1-methylethyl)-6-methyl-, maleate (1:1) (salt);Ergoline-8-carboxamide, 9, 10-didehydro-N- (2-hydroxy-1-methylethyl)-6-methyl-, [8.beta.(S)]-, (Z)-2-butenedioate (1:1) (salt);Ergonovine, maleate (1:1) (salt);Ergoline-8-carboxamide,9,10-didehydro-N- [(1S)-2-hydroxy-1-methylethyl]-6-methyl-,(8a)-,(2Z)-2-butenedioate (1:1) (salt);Oxytocic;Ergometrine maleate (1:1);Ergot;Ergometrine;Ergometrine maleate;ERGOT;ERGONO-VINE, MALEATE (1:1) (SALT);CRUDE ERGOT;
CAS:129-51-1
EINECS: 204-953-5
Molecular Formula: C19H23N3O2.C4H4O4
Molecular Weight: 441.47698
InChI: InChI=1S/C19H23N3O2.C4H4O4/c1-11(10-23)21-19(24)13-6-15-14-4-3-5-16-18(14)12(8-20-16)7-17(15)22(2)9-13;5-3(6)1-2-4(7)8/h3-6,8,11,13,17,20,23H,7,9-10H2,1-2H3,(H,21,24);1-2H,(H,5,6)(H,7,8)/b;2-1-/t11-,13+,17+;/m0./s1
Molecular Structure: (C19H23N3O2.C4H4O4) Metriclavin;Ergonovine, maleate (1:1);Ergotrate Maleate;Ergomet;Cornocentin;Ergometrine maleate (JP1...
Properties
Transport:UN 1544 6
Melting Point: ca. 200 C
Flash Point: 635.2 ºCat 760 mmHg
Boiling Point: 635.2 ºCat 760 mmHg
Density:1.3g/cm3
Stability:Stable, but may be heat sensitive - store at -20 C. Incompatible with strong oxidizing agents.
Water Solubility:Sparingly soluble in water and ethanol (~750 g/l) TS; practically insoluble in ether R
Solubility:Sparingly soluble in water and ethanol (~750 g/l) TS; practically insoluble in ether R
Appearance:white or faintly yellow, crystalline powder; odourless.
Specification:

  Ergonovine maleate (CAS NO.129-51-1) is used in chemical reagents, organic intermediates, fine chemicals, pharmaceutical research and development.
  A deadly human poison. Experimental poison by intravenous route. Experimental reproductive effects. Human systemic effects: hypermotility, diarrhea, cyanosis, thirst, tachycardia, confusion, coma, central nervous system symptoms, gangrene; circulatory changes can follow ingestion. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also individual components. Ergonovine maleate (CAS NO.129-51-1) is one kind of dangerous material, because it has toxic by inhalation, in contact with skin and if swallowed, In case of accident or if you feel unwell, seek medical advice immediately (show label where possible). And its toxicity is:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LDLo intravenous 80mg/kg (80mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SKIN AND APPENDAGES (SKIN): HAIR: OTHER		 Journal of Pharmacology and Experimental Therapeutics. Vol. 54, Pg. 398, 1935.
infant TDLo intramuscular 40ug/kg (0.04mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

LUNGS, THORAX, OR RESPIRATION: CYANOSIS		 JAMA, Journal of the American Medical Association. Vol. 250, Pg. 729, 1983.
man LDLo unreported 15mg/kg (15mg/kg)   "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
mouse LD50 intravenous 8260ug/kg (8.26mg/kg)   Toxicology and Applied Pharmacology. Vol. 23, Pg. 537, 1972.

Packinggroup: III
Flash Point: 635.2 ºCat 760 mmHg
Storage Temperature: −20°C
Safety Data
 

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