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1,3-Propanediol,2-[(5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraen-1-yloxy]- (222723-55-9)

Identification
Name:1,3-Propanediol,2-[(5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraen-1-yloxy]-
Synonyms:2-[((11Z, 14Z)-Icosa-5, 8, 11, 14-tetraenyl)oxy]-propane-1, 3-diol;2-Arachidonyl glycerol ether;Noladin ether;
CAS:222723-55-9
Molecular Formula: C23H40O3
Molecular Weight: 364.5619
InChI: InChI=1S/C23H40O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-26-23(21-24)22-25/h6-7,9-10,12-13,15-16,23-25H,2-5,8,11,14,17-22H2,1H3/b7-6-,10-9-,13-12-,16-15-
Molecular Structure: (C23H40O3) 2-[((11Z, 14Z)-Icosa-5, 8, 11, 14-tetraenyl)oxy]-propane-1, 3-diol;2-Arachidonyl glycerol ether;Nola...
Properties
Density:0.948 g/cm3
Refractive index:1.502
Water Solubility:15mg/ml soluble in DMSO or dimethyl formamide; 0.5mg/ml soluble in a 1:1 solution of ethanol:PBS ( 7.2) (dilute the ethanol solution with PBS).
Solubility:15mg/ml soluble in DMSO or dimethyl formamide; 0.5mg/ml soluble in a 1:1 solution of ethanol:PBS ( 7.2) (dilute the ethanol solution with PBS).
Biological Activity: Endogenous agonist for the GPR55 and CB 1 receptors (EC 50 values are 10 and 37 nM respectively) that displays selectivity over CB 2 receptors (K i values are 21.2 nM and > 3mM at CB 1 and CB 2 respectively). Causes sedation, hypothermia, intestinal immobility and mild antinociception in vivo . Attenuates sensory neurotransmission in rat mesenteric arteries via GPR55. Also available as part of the Endocannabinoid Tocriset™ .
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