Biological Activity: | Potent, brain penetrant, orally active 5-HT 6?antagonist. Displays > 200-fold selectivity for 5-HT 6?over other 5-HT receptors (pK i values are 9.11, 8.81 and 9.02? for human recombinant, native rat and native human 5-HT 6 receptors respectively). |