| Identification | |
| Name: | 5,8,11,14-Eicosatetraenamide,N-(2-hydroxyethyl)-, (5Z,8Z,11Z,14Z)- |
| Synonyms: | 5,8,11,14-Eicosatetraenamide,N-(2-hydroxyethyl)-, (all-Z)-; Anandamide; Arachidonylethanolamide;N-(2-Hydroxyethyl)arachidonamide; N-(2-Hydroxyethyl)arachidonylamide;N-Arachidonoylethanolamide; N-Arachidonylethanolamide;N-Arachidonylethanolamine |
| CAS: | 94421-68-8 |
| Molecular Formula: | C22H37 N O2 |
| Molecular Weight: | 347.5347 |
| InChI: | InChI=1/C22H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-22(25)23-20-21-24/h6-7,9-10,12-13,15-16,24H,2-5,8,11,14,17-21H2,1H3,(H,23,25)/b7-6-,10-9-,13-12-,16-15- |
| Molecular Structure: |  |
| Properties | |
| Transport: | UN 1170 3 |
| Flash Point: | 269.7 ºC |
| Boiling Point: | 522.3 ºCat 760 mmHg |
| Refractive index: | 1.503 |
| Appearance: | light yellow oil |
| Specification: |
Anandamide (CAS NO.94421-68-8), known as N-arachidonoylethanolamine or AEA, is an endogenous cannabinoid neurotransmitter found in animal and human organs, especially in the brain. It was isolated. It is degraded by the fatty acid amide hydrolase (FAAH) enzyme which converts anandamide into ethanolamine and arachidonic acid. As such, inhibitors of FAAH lead to elevated anandamide levels and are being pursued for therapeutic use. |
| Biological Activity: | Endogenous cannabinoid and vanilloid receptor agonist, in water-soluble emulsion (for details see TocrisolveTM 100). K i values are 89 and 371 nM for CB 1 and CB 2 receptors respectively; EC 50 values are 18, 31 and 27 nM at GPR55, CB 1 and CB 2 respectively; pK i = 5.68 for rVR1. Also blocks TNF- α -induced NF-kB activation via direct inhibition of IKK. Also available as the pure oil dissolved in ethanol (N-(2-Hydroxyethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide ). |
| Flash Point: | 269.7 ºC |
| Storage Temperature: | −20°C |
| Color: | light yellow |
| Safety Data | |
| Hazard Symbols |
F: Flammable
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